Liposome vectors for in vivo gene delivery

Current Protocols in Human Genetics
M WhitemoreLeaf Huang

Abstract

Gene therapy with nonviral, cationic liposome-based vectors has demonstrated promising results in a variety of in vivo models and some clinical trials. In contrast to viral vectors, cationic liposome-based vectors usually induce just mild inflammatory reactions, making them suitable for repeated injections in animals. This unit describes the preparation and delivery of two liposome-based vectors Gene therapy with nonviral, cationic liposome-based vectors has demonstrated promising results in a variety of in vivo models.

References

Aug 30, 1991·Biochemical and Biophysical Research Communications·X Gao, L Huang
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P L FelgnerM Danielsen
Feb 15, 1995·Biochemical and Biophysical Research Communications·H Hofland, L Huang
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J NabelA E Chang
Feb 12, 1998·Gene Therapy·F L SorgiL Huang
Feb 21, 1998·Trends in Biotechnology·P D RobbinsS C Ghivizzani

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Citations

Sep 8, 2010·Pharmaceutical Research·Wei-Yun Sheng, Leaf Huang

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