Liposomes: a promising carrier for respiratory syncytial virus therapeutics

Expert Opinion on Drug Delivery
Sameer JoshiShree R Singh

Abstract

Introduction: Human respiratory syncytial virus (RSV) is a common respiratory virus that causes severe lower respiratory tract infection in infants, children and aged adults. Currently, there is no active prophylaxis present in the market for RSV infection; however, there are over a dozen compounds being tested in the laboratory as well as clinical trials. To increase the efficiency and safety of these therapeutics, there is a need for delivery vehicles. Areas covered: Liposomes can be used for delivering anti-RSV agents with the advantage of modulating and eliciting the desired adjuvant effect by the different combination of lipids. This review discusses the promising application of liposome for anti-RSV therapeutics. Expert opinion: Liposomes are attracting attention for delivery of pulmonary therapeutics, since they offer compatibility for delivering drugs, vaccines and other therapeutic molecules. Variation in liposome size and composition gives flexibility for the amount and number of deliverables, whilst targeted delivery with the capability for immunomodulation makes liposomes a promising candidate for RSV therapeutic applications.

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Mabrey, J M Sturtevant
Nov 15, 1974·Nature·A G Allison, G Gregoriadis
Jan 21, 1972·European Journal of Biochemistry·G Gregoriadis, B E Ryman
Aug 1, 1972·The Biochemical Journal·G Gregoriadis, B E Ryman
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Mar 1, 1995·Current Biology : CB·F M Hughson
Jun 1, 1993·Journal of Applied Physiology·J T BergM F Tsan
Aug 1, 1996·Archives of Pediatrics & Adolescent Medicine·B W Donnelly
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·P M BlagoevaB T Atanassov
Jul 17, 1998·Clinical Microbiology Reviews·R A Dudas, R A Karron
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·X ZhaoP S Kim
May 1, 2001·Bioorganic & Medicinal Chemistry Letters·A A NikitenkoT Z Wang
Jul 14, 2001·Chemistry & Biology·V RazinkovG Krishnamurthy
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Clayton C HuntleyJohn F O'Connell
Feb 23, 2002·Vaccine·David R Nalin
Apr 1, 1971·FEBS Letters·G GregoriadisB E. Ryman
May 9, 2002·British Medical Bulletin·S B Gordon, R C Read
Jul 1, 1995·The Journal of Nutritional Biochemistry·Charles E. IsaacsHalldor Thormar
Jun 18, 2002·American Journal of Obstetrics and Gynecology·Everett F MagannJohn C Morrison
Mar 5, 2003·Biochemical and Biophysical Research Communications·Enxiu WangGeorge F Gao
Jul 18, 2003·The American Journal of Cardiology·Robert S Rosenson, Wolfgang Koenig
Nov 26, 2003·Antiviral Research·Koen AndriesPhilip R Wyde
Dec 5, 2003·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn
May 1, 2004·BMJ : British Medical Journal·Jenny HandforthJon S Friedland
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Christopher CianciMark Krystal
Sep 3, 2004·American Journal of Obstetrics and Gynecology·Suneet P ChauhanJack H Klausen
Oct 19, 2004·International Journal of Pharmaceutics·A R MohammedY Perrie
Apr 29, 2005·The New England Journal of Medicine·Ann R FalseyEdward E Walsh

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