Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors

Science
J N WeinsteinD S Zaharko

Abstract

Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to 42 degrees C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.

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