Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In Vivo Studies

AAPS PharmSciTech
Huili LiXiangrong Song

Abstract

The objective of this study was to investigate the potential of liposomes as an ophthalmic delivery system for brinzolamide (Brz) to enhance the local glaucomatous therapeutic effect. The liposomes of Brz (Brz-LPs) were produced by the thin-film dispersion method with a particle size of 84.33 ± 2.02 nm and an entrapment efficiency of 98.32 ± 1.61%. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) analysis proved that Brz was successfully entrapped into Brz-LPs. Brz-LPs displayed a biphasic release pattern in vitro with burst release initially and sustained release afterwards. The corneal permeability was measured using modified Franz-type diffusion cells, and Brz-LPs showed 6.2-fold increase in the apparent permeability coefficient when compared with the commercial available formulation (B rz-Sus). Moreover, Brz-LPs (1 mg/mL Brz) showed a more sustained and effective intraocular pressure reduction (5-10 mmHg) than Brz-Sus (10 mg/mL Brz) in white New Zealand rabbits. Therefore, Brz-LPs were a hopeful formulation of Brz for glaucoma treatment and worthy of further investigation.

References

Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J Allen ZhangImran Ahmad
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luna DingChi-Hwa Wang
Mar 12, 2005·The AAPS Journal·Anand Babu Dhanikula, Ramesh Panchagnula
Apr 6, 2007·AAPS PharmSciTech·Rania M HathoutAhmed S Guinedi
Apr 22, 2008·Journal of Pharmaceutical Sciences·E VegaM A Egea
Mar 11, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kohei HironakaHirofumi Takeuchi
Oct 28, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Himanshu GuptaGaurav Mittal
Aug 4, 2010·Journal of Drug Targeting·Himanshu GuptaGaurav Mittal
Jan 26, 2012·International Journal of Nanomedicine·Jayaganesh V NatarajanSubbu S Venkatraman
Nov 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyun Jung JungAnuj Chauhan
Jul 9, 2013·Journal of Pharmacy & Bioallied Sciences·Himanshu GuptaGaurav Mittal
Aug 31, 2013·Carbohydrate Polymers·Ying ZhangXiangrong Song

❮ Previous
Next ❯

Citations

Oct 22, 2016·Drug Delivery and Translational Research·I Bravo-OsunaR Herrero-Vanrell
Jun 29, 2017·Expert Opinion on Drug Safety·Jed Asher Lusthaus, Ivan Goldberg
Apr 21, 2018·The Journal of Pharmacy and Pharmacology·Hubert NguyenCrispin R Dass
Nov 6, 2018·Current Medicinal Chemistry·Xiao XiaoWenliang Li
Aug 2, 2017·Drug Development and Industrial Pharmacy·Amira Mohamed MohsenAbeer A A Salama
Jan 9, 2021·Expert Opinion on Drug Delivery·José Javier López-CanoIrene Teresa Molina-Martínez
Nov 24, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nada M El HoffySeham A Elkheshen
Sep 18, 2020·Current Pharmaceutical Design·Karthikeyan KesavanVal C Sheffield

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.