Liposomes as cyclosporin A carriers: positively charged lecithin-cholesterol liposomes associated with cyclosporin A do not inhibit biosynthesis of mitochondrial polyglycerophosphatides and microsomal phosphatidylinositol

Journal of Microencapsulation
L Stuhne-Sekalec, N Z Stanacev

Abstract

Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and microsomal membranes, respectively, isolated from rat liver. These results are explained by possible protection of the liposomes by cyclosporin A against phospholipase A2 hydrolysis.

References

Jun 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·V G Zin'kovskiĭS A Andronati
May 1, 1986·Transplantation·L Stuhne-SekalecN Z Stanacev
Aug 1, 1972·Canadian Journal of Biochemistry·J B Davidson, N Z Stanacev
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

Related Concepts

stearylamine hydrochloride
phosphatidylglycerophosphate
Amines
Epicholesterol
Cyclosporins
Drug Carriers
Niosomes
Microsomes
Mitochondria
Phosphatidylcholines

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