Liposomes as multicompartmental carriers for multidrug delivery in anticancer chemotherapy

Drug Delivery and Translational Research
Donato CoscoM Fresta

Abstract

A new PEGylated liposomal formulation containing both gemcitabine (GEM) and paclitaxel (PTX) was investigated in order to realize an innovative multidrug carrier (MDC) to test on human cancer cells. The MDC in question was realized by the liposome extrusion method. Photocorrelation spectroscopy was used for the physicochemical characterization of the vesicular carriers. In vitro cytotoxicity was studied through MTT testing. The contemporary presence of the two antitumoral compounds induced no destabilization phenomena in the liposomal structure. The extrusion method provided vesicles with mean sizes of ∼100 nm and a zeta-potential of ∼ -10 mV. The liposomal MDC showed a high drug loading capacity (∼90% and ∼80% for GEM and PTX, respectively) as well as a controlled release of the active compounds over a 24-h period. Cell viability testing on Michigan Cancer Foundation-7 human breast cancer cells evidenced the MDC as having a stronger cytotoxic effect with respect to the active compounds tested in free and liposomal formulations, both as single molecules and in association. Flow cytometry furnished evidence of the synergistic in vitro antitumoral action between the GEM and PTX co-encapsulated the liposomal MDC. This formulation ...Continue Reading

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Citations

Dec 4, 2013·Future Oncology·Emanuela GentileChristian Celia
Oct 31, 2013·Pharmaceutical Research·Lívia Palmerston MendesEliana Martins Lima
Jan 19, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shengjie LuKoon Gee Neoh
Apr 23, 2015·International Journal of Pharmaceutics·Donato CoscoMassimo Fresta
Mar 22, 2015·Drug Delivery and Translational Research·Dwayne Koot, Duncan Cromarty
Nov 11, 2016·Colloids and Surfaces. B, Biointerfaces·Maria Chiara CristianoMassimo Fresta
Jul 11, 2018·Frontiers in Chemistry·Patrícia M CarvalhoMarco M Domingues
Dec 25, 2019·Drug Delivery and Translational Research·Gauthami PulivendalaChandraiah Godugu
Jan 19, 2020·Pharmaceutics·Silvia VociDonato Cosco
Feb 6, 2021·International Journal of Pharmaceutics·Nicola d'AvanzoHélder A Santos

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