PMID: 9167942Apr 1, 1997Paper

Liposomes containing alpha-tocopherol and ascorbate are protected from an external oxidant stress

Free Radical Research
R E WatersJ M May

Abstract

The interaction between alpha-tocopherol and ascorbate in protecting membrane lipids from peroxidation was studied in unilamellar liposomes in which alpha-tocopherol was incorporated into the liposomal membrane, and ascorbate was trapped within the vesicles. Extravesicular ferricyanide was reduced by ascorbate-derived electrons, and this was enhanced by the presence of alpha-tocopherol in the lipid bilayer. When a water-soluble free radical initiator was added to the outside of liposomes, intravesicular ascorbate prevented oxidation of alpha-tocopherol, and this effect was associated with complete protection against peroxidation of membrane lipids. These results suggest that ascorbate-dependent recycling of alpha-tocopherol can protect biological membranes from peroxidation by oxidants originating across the membrane bilayer from ascorbate.

References

Jul 1, 1987·Chemistry and Physics of Lipids·E Niki
Sep 13, 1995·Biochimica Et Biophysica Acta·J M MayR R Whitesell
Dec 1, 1963·Analytical Biochemistry·M AVRON, N SHAVIT

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Citations

Apr 3, 2003·Cancer Detection and Prevention·R E J Mitchel, R A McCann
Feb 24, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S R PinnellM Levine
Mar 7, 2001·Antioxidants & Redox Signaling·J M May, Z C Qu
Nov 8, 2005·Chemical & Pharmaceutical Bulletin·Cuiping ChiKazunori Anzai
Mar 14, 2002·Biochemical and Biophysical Research Communications·James M MayRaymond F Burk
Nov 6, 2008·Reproductive Biomedicine Online·Francisco Javier Martín-RomeroIgnacio Santiago Alvarez
Sep 1, 2005·Cell Biochemistry and Function·Ligia Maria ClaroAguinaldo José do Nascimento
Nov 16, 1999·Biochimica Et Biophysica Acta·J M May, Z C Qu
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M May
Jan 11, 2003·Journal of the American Academy of Dermatology·Sheldon R Pinnell

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