Liposomes encapsulating Aloe vera leaf gel extract significantly enhance proliferation and collagen synthesis in human skin cell lines

Journal of Oleo Science
Makoto TakahashiKoji Wada

Abstract

Aloe vela leaf gel extract (AGE) are widely used as cosmetic and pharmaceutical ingredients because of its versatile skin care properties. In order to enhance the bioavailability of AGE, liposomes encapsulating AGE were prepared and examined for their interfacial and biochemical properties. The liposomes prepared from a soybean lecithin (SLP-WHITE, 1.0 wt%) by the Bangham method gave relatively a good trapping efficiency up to the AGE concentration of 0.5 wt%. The stable liposomes were then prepared from 1.0 wt% of SLP-WHITE and different concentrations of AGE by the mechanochemical method using a homogenizer and microfluidizer. The liposomes obtained from 0.25 wt% of AGE were confirmed to be small unilamellar vesicles with a diameter of less than 200 nm, and remained well dispersed for at least two weeks. The obtained liposomes encapsulating AGE were further examined for the effects on proliferation and type I collagen synthesis in normal human neonatal skin fibroblasts, NB1RGB cells. Liposomal AGE clearly showed higher proliferation rate than that of AGE alone. In addition, compared to the control, liposomal AGE significantly increased the collagen synthesis by 23%, while AGE alone showed a small effect. Liposomal AGE was als...Continue Reading

References

Oct 11, 1991·International Journal of Dermatology·R A YatesL E King
Aug 1, 1985·Experimental Cell Research·M NakanishiY Okada
Jan 1, 1987·Annals of the New York Academy of Sciences·R I SchwarzN Owens
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Mar 21, 1998·Journal of Ethnopharmacology·P ChithraG Chandrakasan
Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S ZellmerJ Lasch
Jan 7, 2000·Journal of Ethnopharmacology·T Reynolds, A C Dweck
Jun 9, 2001·International Journal of Pharmaceutics·C H LeeY Lee
Oct 18, 2001·International Journal of Pharmaceutics·G BetzG Imanidis
Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akira Yagi, Satoshi Takeo
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshikazu InohMamoru Nakanishi
May 1, 2004·Critical Reviews in Food Science and Nutrition·Kojo Eshun, Qian He
Oct 10, 2006·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Susi Elaine Dal'BeloPatrícia Maria Berardo Gonçalves Maia Campos
Dec 1, 1987·Planta medica·A YagiN Morinobu
May 8, 2008·Bioscience, Biotechnology, and Biochemistry·Makoto TakahashiKoji Wada
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Josias H Hamman
Mar 21, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nari YunSun-Mee Lee

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Citations

May 9, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·T LajunenY Takashima
Jan 30, 2013·Drug Development and Industrial Pharmacy·Guanyu ChenJingyuan Wen
Mar 15, 2012·Expert Opinion on Drug Delivery·Yahya Rahimpour, Hamed Hamishehkar
Aug 26, 2014·Microscopy Research and Technique·Andrea Aparecida de AroEdson Rosa Pimentel
Dec 17, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Chiara GiulianiAnnarita Stringaro
Feb 1, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Masoumeh Ghafarzadeh, Ali Eatemadi
Mar 30, 2017·International Journal of Molecular Sciences·Raffaele ContePierfrancesco Cerruti
Dec 17, 2019·Pharmaceutical Nanotechnology·Giulia AnderluzziYvonne Perrie
May 17, 2017·Advanced Pharmaceutical Bulletin·Mehran AlaviMohsen Safaei
Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hyang Seon RoHyeon Yong Lee

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