Liposomes in immunology: impairment of the adjuvant effect of liposomes by incorporation of the adjuvant lysolecithin and the role of macrophages

Immunological Communications
N van Rooijen, R van Nieuwmegen

Abstract

The immune response against HSA (human serum albumin) was studied in rabbits after intravenous injection of various HSA preparations. When HSA was injected one day after, together with or coupled to lysolecithin, a late response was found in twelve out of thirteen rabbits, whereas a minority of the rabbits responded when lysolecithin was omitted. These results confirm the adjuvant activity of lysolecithin. A rapid response starting on day 6 was found in rabbits injected with HSA entrapped in liposomes which had been composed of lecithin, phosphatidic acid and cholesterol (PPC liposomes). The response against liposome entrapped HSA was delayed for about one day when the phospholipid adjuvant lysolecithin was incorporated in the liposomes (LPPC liposomes). Results lend support to the hypothesis that the adjuvant activity of lysolecithin and its opposite inhibition of the adjuvant activity of liposomes are mediated by the same mechanism, i.e. inhibition of enzymatic digestion in lysosomes of macrophages.

References

Apr 1, 1977·Journal of Biochemistry·K InoueS Nojima
Dec 1, 1975·FEBS Letters·Y Fishman, N Citri
Jan 1, 1978·Immunological Communications·N van Rooijen, R van Nieuwmegen
Nov 1, 1978·Stain Technology·N van Rooijen, R van Nieuwmegen
Sep 15, 1975·FEBS Letters·G EytanE Racker
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T YasudaS C Kinsky
Jan 1, 1978·Immunological Reviews·E R Unanue
Jan 1, 1978·International Archives of Allergy and Applied Immunology·C H Tonkin, J Brostoff
Mar 17, 1977·Biochimica Et Biophysica Acta·A M van den BesselaarL L van Deenen
Mar 29, 1977·Biochimica Et Biophysica Acta·J ZborowskiG Scherphof
Dec 15, 1977·Biochimica Et Biophysica Acta·O M de Oliveira FilgueirasH van den Bosch
Jan 1, 1977·Immunological Communications·N van Rooijen, R van Nieuwmegen
Jan 1, 1976·Biochemical Society Transactions·T D HeathB E Ryman
Dec 15, 1976·Experientia·L Mattenberger-KreberA Malnoë
Jan 1, 1976·International Archives of Allergy and Applied Immunology·O Strannegård, G Roupe
Jan 1, 1970·Advances in Immunology·G Weissmann, P Dukor
Feb 10, 1968·Nature·D W Dresser
Jan 1, 1972·Advances in Immunology·E R Unanue
Jan 1, 1973·International Archives of Allergy and Applied Immunology·P G Munder, M Modolell
Nov 15, 1974·Nature·A G Allison, G Gregoriadis
Jul 20, 1973·Nature·G Gregoriadis, R A Buckland
Aug 1, 1972·The Biochemical Journal·G Gregoriadis, B E Ryman
Nov 1, 1969·Analytical Biochemistry·A A Spector, J C Hoak
Aug 22, 1970·Nature·A R PooleJ A Lucy

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Citations

Jan 1, 1984·Journal of the Neurological Sciences·H ReiberM G Rumsby
Mar 1, 1985·Vaccine·D E Stewart-Tull
Sep 1, 1981·The Journal of Surgical Research·J D BeattyF Paraskevas
Jan 1, 1982·Immunological Communications·D P SarkarM K Das
Jan 1, 1984·Immunology Letters·N Latif, B K Bachhawat

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