Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.

Infection and Immunity
A SugiyamaH Takada

Abstract

Lipoteichoic acids (LTA) from various gram-positive bacteria, including oral streptococci such as Streptococcus sanguis, enhanced the production of hepatocyte growth factor (HGF) (scatter factor) by human gingival fibroblasts in culture, whereas lipopolysaccharides (LPS) from various gram-negative bacteria did not. In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect. LTA and recombinant human interleukin 1 alpha enhanced synergistically the production of HGF/SF in human gingival fibroblast cultures. Recombinant human HGF, in turn, enhanced the proliferation of human gingival epithelial cells in culture.

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Citations

Jun 19, 2002·The Journal of Experimental Medicine·Siegfried MorathThomas Hartung
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne DeiningerThomas Hartung
Feb 1, 2003·European Journal of Oral Sciences·Scott Thomas William McKeownChristopher Robert Irwin
Jul 27, 2012·Renal Failure·Magdalena Wilczyńska-BorawskaMichał Myśliwiec
Dec 17, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Takehito SuzukiTatsuya Takizawa
Dec 15, 2015·Periodontology 2000·Katrin M JaedickeJohn J Taylor
Jan 18, 2002·Infection and Immunity·Siegfried MorathThomas Hartung
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Oct 27, 2010·Transplantation·Takehito ImadoHajime Sano
Sep 30, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Anna GustafssonLennart Ljunggren
Jun 20, 2014·ISRN Inflammation·John J Taylor
Oct 25, 2016·FEBS Letters·Mitsuhiro HisadomeTetsuya Matsuguchi
Apr 19, 2013·Journal of Periodontology·Johanna LönnNils Ravald
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SugawaraH Takada
Sep 19, 2002·Periodontology 2000·Frank A Roberts, Richard P Darveau
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Dec 2, 2017·Journal of Investigative and Clinical Dentistry·Sanjeela GuruShyam Padmanabhan
Aug 28, 2021·International Journal of Molecular Sciences·Rajdeep ChakrabortyHonghua Hu

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