Lipoteichoic acid from viridans streptococci induces the production of tumor necrosis factor and nitric oxide by murine macrophages

The Journal of Infectious Diseases
B K EnglishJ L Shenep

Abstract

Bacterial endotoxin or lipopolysaccharide is the major proinflammatory component of gram-negative bacteria, but the components of gram-positive bacteria that trigger the inflammatory cascade are poorly understood. Lipoteichoic acid (LTA) purified from 2 strains of viridans streptococci induced the accumulation of tumor necrosis factor (TNF) mRNA and protein by the murine macrophage cell line RAW 264.7 in a dose- and time-dependent manner. Furthermore, in the presence of recombinant interferon-gamma, LTA from both strains of viridans streptococci provoked the accumulation of inducible nitric oxide (NO) synthase mRNA and the production of NO. Together these observations indicate that LTA can trigger macrophage activation and the production of TNF and NO and suggest that LTA may be an important determinant of the host inflammatory response to gram-positive infection.

Citations

May 26, 1999·Infectious Disease Clinics of North America·S Sriskandan, J Cohen
Mar 18, 2000·International Journal of Antimicrobial Agents·J L Shenep
Sep 21, 2010·Nitric Oxide : Biology and Chemistry·Zdeněk ZídekEva Kmoníčková
Jan 6, 2004·Bone Marrow Transplantation·N IhendyaneA Norrby-Teglund
Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·L M PlitnickE J Gosselin
Nov 24, 1999·Infection and Immunity·M G ScottR E Hancock

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