Lipotoxicity, overnutrition and energy metabolism in aging.

Ageing Research Reviews
Marc Slawik, Antonio Vidal-Puig

Abstract

The safest place to store lipids is the white adipose tissue, but its storage capacity may become saturated resulting in excess of fat "overspilled" to non-adipose tissues. This overspill of fat occurs in apparently opposite pathological states such as lipodistrophy or obesity. When the excess of energy is redirected towards peripheral organs, their initial response is to facilitate the storage of the surplus in the form of triacylglycerol, but the limited triacylglycerol buffer capacity becomes saturated soon. Under these conditions excess of lipids enter alternative non-oxidative pathways that result in production of toxic reactive lipid species that induce organ-specific toxic responses leading to apoptosis. Reactive lipids can accumulate in non-adipose tissues of metabolically relevant organs such as pancreatic beta-cells, liver, heart and skeletal muscle leading to lipotoxicity, a process that contributes substantially to the pathophysiology of insulin resistance, type 2 diabetes, steatotic liver disease and heart failure. The effects of this lipotoxic insult can be minimised by several strategies: (a) decreased incorporation of energy, (b) a less orthodox approach such as increased adipose tissue expandability and/or (c) ...Continue Reading

References

Dec 10, 1992·The New England Journal of Medicine·J Y Wei
Jan 1, 1995·Obesity Research·R N BaumgartnerA F Roche
Jan 1, 1993·The American Journal of Clinical Nutrition·F FroidevauxE Jéquier
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Aug 1, 1997·Journal of the American Geriatrics Society·J L Kirkland, D E Dobson
Feb 14, 1998·The Journal of Clinical Investigation·J B KimB M Spiegelman
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·S CasesR V Farese
Jan 23, 1999·The Journal of Clinical Investigation·A DresnerG I Shulman
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R H UngerL Orci
Jun 4, 1999·Seminars in Cell & Developmental Biology·J K Sethi, G S Hotamisligil
Jun 11, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·K HottaB C Hansen
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HigaR H Unger
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Jan 12, 2000·Journal of Pediatric Gastroenterology and Nutrition·M Rashid, E A Roberts
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Jun 17, 2000·Biochimica Et Biophysica Acta·J Kerner, C Hoppel
Aug 15, 2000·Annual Review of Nutrition·C HolmJ A Contreras
Oct 21, 2000·European Journal of Clinical Nutrition·M EliaR J Stubbs
Nov 30, 2000·The Journal of Biological Chemistry·Y LeeR H Unger
Dec 29, 2000·The American Journal of Medicine·A Garg
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Z W WangR H Unger
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R H Unger, L Orci
Apr 4, 2001·The Journal of Clinical Investigation·H C ChiuJ E Schaffer
Apr 12, 2001·Seminars in Liver Disease·Y Falck-YtterA J McCullough
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I KaragiannidesJ L Kirkland
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Nov 15, 2001·Obesity Research·M Elia
Dec 1, 2001·Endocrinology and Metabolism Clinics of North America·G Boden
Jan 18, 2002·Nature·Yasuhiko MinokoshiBarbara B Kahn
Jan 31, 2002·Annual Review of Medicine·Roger H Unger
Apr 12, 2002·FEBS Letters·Abdul G DullooJosiane Seydoux
Jun 25, 2002·Annals of the New York Academy of Sciences·Eric Jéquier

❮ Previous
Next ❯

Citations

Apr 23, 2011·Der Radiologe·M Slawik, F Beuschlein
Aug 3, 2010·Molecular and Cellular Biochemistry·Kalpana BallalHeinrich Taegtmeyer
Feb 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T PriegoC Picó
Jul 27, 2007·Journal of Toxicology and Environmental Health. Part a·Mi Young AhnByung Mu Lee
Jun 6, 2009·Archives of Animal Nutrition·Kelly S SwansonLawrence B Schook
Jun 5, 2010·Journal of Medicinal Food·John G BabishMatthew L Tripp
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnaud BernardJean Demarquoy
Jun 6, 2008·Current Opinion in Rheumatology·Gustavo Duque
Jun 10, 2011·Pancreas·Yolanda Gómez-PérezAna M Proenza
Mar 6, 2008·Annual Review of Biochemistry·Michael P Murphy, Linda Partridge
Jun 15, 2011·The Journal of Clinical Investigation·Jeanna C PermanJan Borén
Jun 3, 2011·The Journal of Clinical Investigation·Kai SunPhilipp E Scherer
Feb 13, 2010·Molecular Endocrinology·Lei O LiRosalind A Coleman
Mar 30, 2012·The Journal of Endocrinology·Paramita M GhoshAmrita Kamat
Feb 11, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Zhi-Hong WangJing-Hsien Chen
Oct 20, 2014·Reviews in Endocrine & Metabolic Disorders·Patrick MathieuJean-Pierre Després
Aug 1, 2008·Nutrition Reviews·Deanna M Minich, Jeffrey S Bland
Jun 11, 2014·Annals of Medicine·Cristina ContrerasMiguel López
Jul 30, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Min Hi ParkHae Young Chung
Feb 6, 2016·Age·Magdalena Jura, Leslie P Kozak
Jan 9, 2016·Nature Communications·KyeongJin KimUtpal B Pajvani
Jul 5, 2015·Biochimica Et Biophysica Acta·Jiyoung KimMyriam Gorospe
Aug 24, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ayako SuzukiAnna Mae Diehl
Feb 16, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S TyrovolasD B Panagiotakos
Oct 13, 2009·Biochimica Et Biophysica Acta·Adam R Wende, E Dale Abel
Oct 3, 2009·Biochimica Et Biophysica Acta·Pablo B Martínez de MorentinMiguel López
Jul 7, 2009·Ageing Research Reviews·Jennifer L KukRobert Ross
Nov 11, 2008·Archives of Medical Research·Maria Eugenia Frigolet Vázquez-VelaArmando R Tovar
Mar 18, 2008·Drug Discovery Today·Shivani MittraPradip K Bhatnagar
Jan 19, 2008·The International Journal of Biochemistry & Cell Biology·Patrick MathieuJean-Pierre Després
Feb 14, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Miguel LópezAntonio Vidal-Puig
May 26, 2007·The Journal of Pharmacy and Pharmacology·Eun Ju ChoTakuya Okamoto
Aug 13, 2010·Aging Cell·Tamara TchkoniaJames L Kirkland

❮ Previous
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