PMID: 6409462Jan 1, 1983Paper

Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia

Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy
S A Saeed, M D Mitchell

Abstract

The formation of lipoxygenase metabolites by human uterine and intrauterine tissues was evaluated using [1-14C]arachidonic acid (AA) as substrate. The major lipoxygenase product synthesized by human amnion, decidua vera and placenta was identified as 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE); smaller amounts of 5-HETE and 5-HETE (lactone form) were also formed. In chorion laeve only a trace amount of 12-HETE was detected. Human myometrium and cervical tissue converted [1-14C]AA to 5-HETE and 12-HETE in almost equal amounts. The formation of lipoxygenase products in all tissues was markedly inhibited by nordihydroguaiaretic acid (NDGA) an inhibitor of lipoxygenase activity and slightly stimulated or inhibited by indomethacin, an inhibitor of cyclooxygenase activity. These results are indicative that uterine and intrauterine tissues are probably potential sources of lipoxygenase products during pregnancy and parturition. Since 12-hydroperoxy-eicosatetraenoic acid (12-HPETE), the labile precursor of 12-HETE potently inhibits prostacyclin biosynthesis, our findings are suggestive of the possibility that aberrant lipoxygenase activities may contribute to the complications of pre-eclampsia.

References

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Citations

Mar 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P MoonenM J Keirse
Oct 1, 1989·American Journal of Obstetrics and Gynecology·C A HubelM K McLaughlin
Jun 6, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Pia M VillaRisto Kaaja
Jan 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W Gu, G E Rice
Dec 1, 1990·Thrombosis Research·G BiagiS Coccheri
May 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M D Mitchell, J M Koenig
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·O Ylikorkala, L Viinikka
Apr 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M P RoseM G Elder
Nov 5, 2019·American Journal of Reproductive Immunology : AJRI·Luiza Oliveira PerucciAndré Talvani
Aug 6, 1986·Biochimica Et Biophysica Acta·S FlatmanT F Slater

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