Lipoxygenase and cyclooxygenase blockade by BW755C does not prevent the secondary phase of septic pulmonary hypertension

Prostaglandins, Leukotrienes, and Essential Fatty Acids
C HammermanV Hill

Abstract

The infusion of Group B beta hemolytic streptococci (GBS) in newborn animals generates a dual phase pulmonary hypertensive response. The initial, acute phase responds to cyclooxygenase or thromboxane inhibition, and appears to be thromboxane mediated. The second phase is characterized by a more moderate rise in pulmonary vascular resistance, accompanied by an increase in microvascular permeability. It has been speculated that this phase may be leukotriene mediated. In an attempt to clarify this, we have studied and compared the effects of the thromboxane synthetase inhibitor, Dazmegrel (DAZ), and the combined cyclooxygenase/lipoxygenase inhibitor, BW755C, on the cardiopulmonary hemodynamics of the secondary phase of GBS induced pulmonary hypertension in newborn piglets. Ten piglets were infused with GBS, and all animals developed a significant increase in pulmonary artery pressure (to 39 +/- 5 and 36 +/- 5 mmHg for DAZ and BW755C animals respectively). After one hour of GBS, either DAZ or BW755C was administered. Data were collected for another two hours following drug administration. GBS infusion was continued throughout. Both DAZ and BW755C were associated with transient, acute reductions in pulmonary artery pressure (to 22 +...Continue Reading

References

Jun 15, 1979·Biochemical Pharmacology·G A HiggsJ R Vane
Sep 1, 1977·Analytical Biochemistry·F A FitzpatrickF F Sun
Oct 1, 1987·The American Review of Respiratory Disease·W SeegerH Neuhof
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G A HiggsJ R Vane

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Citations

Jun 16, 2012·TheScientificWorldJournal·Raquel Pastréllo HirataLuis Vicente Franco de Oliveira
Sep 6, 2005·International Urology and Nephrology·Fred G Silva

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