Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol

Biochemical and Biophysical Research Communications
J Z Byczkowski, A P Kulkarni

Abstract

Metabolism of resolved radioactive stereoisomer, [14C](+)-benzo-(a)pyrene-trans-7,8-dihydrodiol by highly purified soybean lipoxygenase plus linoleic acid was investigated. Trans-anti-7,8,9,10-tetrahydrotetrol, the product of hydrolytic breakdown of ultimate mutagenic benzo(a)pyrene-anti-7,8-dihydrodiol,9,10-epoxide, was detected as a major metabolite. The epoxidation, depended on the enzyme concentration and was inhibited by nordihydroguaiaretic acid. This study provides evidence on the ability of lipoxygenase to catalyze the epoxidation of benzo(a)pyrene-7,8-dihydrodiol.

References

Aug 1, 1987·Bulletin of Environmental Contamination and Toxicology·J Z Byczkowski, T Gessner
Jan 1, 1987·The International Journal of Biochemistry·J Z Byczkowski, T Gessner
Sep 15, 1988·Biochemical and Biophysical Research Communications·A P Kulkarni, D C Cook

❮ Previous
Next ❯

Citations

Jan 1, 1990·Journal of Biochemical Toxicology·J Z Byczkowski, A P Kulkarni
Aug 1, 1994·Journal of Biochemical Toxicology·S K Roy, A P Kulkarni
Nov 1, 1990·Bulletin of Environmental Contamination and Toxicology·J Z Byczkowski, A P Kulkarni
Apr 23, 1992·Biochimica Et Biophysica Acta·J Z Byczkowski, A P Kulkarni
Feb 1, 1992·The International Journal of Biochemistry·A P KulkarniI S Richards
Mar 7, 1996·Biochimica Et Biophysica Acta·E Núñez-DelicadoF García-Carmona
Jun 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P Roy, A P Kulkarni
Mar 1, 1997·Toxicology and Applied Pharmacology·A P Kulkarni, M P Sajan
Feb 1, 1991·Research Communications in Chemical Pathology and Pharmacology·A K Naidu, A P Kulkarni
Apr 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K A Akhilender NaiduA P Kulkarni
Oct 1, 1991·Cancer Letters·S K Roy, A P Kulkarni
May 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J Z Byczkowski, A P Kulkarni
Feb 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·P G Wells, L M Winn
Feb 6, 1999·Carcinogenesis·R A BrooksD J Winton
Jul 9, 1999·Archives of Biochemistry and Biophysics·E Núñez-DelicadoF García-Carmona
Dec 1, 1990·Archives of Biochemistry and Biophysics·M Hamberg, G Hamberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.