Lipoxygenase-derived 9-hydro(pero)xides of linoleoylethanolamide interact with ABA signaling to arrest root development during Arabidopsis seedling establishment

The Plant Journal : for Cell and Molecular Biology
Jantana KeereetaweepKent D Chapman

Abstract

Ethanolamide-conjugated fatty acid derivatives, also known as N-acylethanolamines (NAEs), occur at low levels (μg per g) in desiccated seeds, and endogenous amounts decline rapidly with seedling growth. Linoleoylethanolamide (NAE18:2) is the most abundant of these NAEs in seeds of almost all plants, including Arabidopsis thaliana. In Arabidopsis, NAE18:2 may be oxidized by lipoxygenase (LOX) or hydrolyzed by fatty acid amide hydrolase (FAAH) during normal seedling establishment, and this contributes to the normal progression of NAE depletion that is coincident with the depletion of abscisic acid (ABA). Here we provide biochemical, genetic and pharmacological evidence that a specific 9-LOX metabolite of NAE18:2 [9-hydro(pero)xy linoleoylethanolamide (9-NAE-H(P)OD)] has a potent negative influence on seedling root elongation, and acts synergistically with ABA to modulate the transition from embryo to seedling growth. Genetic analyses using mutants in ABA synthesis (aba1 and aba2), perception (pyr1, pyl1, pyl2, pyl4, pyl5 and pyl8) or transcriptional activation (abi3-1) indicated that arrest of root growth by 9-NAE-H(P)OD requires an intact ABA signaling pathway, and probably operates to increase ABA synthesis as part of a positiv...Continue Reading

References

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Jan 9, 2014·The Plant Journal : for Cell and Molecular Biology·Elison B BlancaflorKent D Chapman

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Citations

Apr 4, 2017·Plant & Cell Physiology·Ayla OenelSusanne Berger
Nov 23, 2017·Annual Review of Plant Biology·Claus Wasternack, Ivo Feussner
Nov 20, 2016·The Journal of Biological Chemistry·Bibi Rafeiza KhanElison B Blancaflor
Aug 3, 2018·Journal of Zhejiang University. Science. B·Li-Jun JuHong-Yan Qi
Jan 21, 2021·Trends in Plant Science·Ashley E Cannon, Kent D Chapman
Jan 11, 2020·Trends in Plant Science·Mina Aziz, Kent D Chapman

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