PMID: 9439765May 1, 1997Paper

Lipoxygenase inhibitors counteract protein kinase C mediated events in human T lymphocyte proliferation

International Journal of Immunopharmacology
N Papadogiannakis, B Barbieri

Abstract

Four structurally unrelated inhibitors of lipoxygenase (LO), i.e. nordihydroguaiaretic acid (NDGA), Esculetin, AA861 and 5,8,11,14-eicosatetraynoic acid (ETYA) suppressed mitogen induced proliferation of human peripheral blood lymphocytes in a dose-dependent manner. The degree of suppression was influenced by the type of the mitogenic stimulus. Receptor mediated stimulation, i.e. through phytohemagglutinin or the anti-CD3 antibody OKT3, was overall less susceptible, whereas proliferation initiated by direct activation of protein kinase C (PKC), i.e. through phorbol myristate acetate or indolactam V, was profoundly suppressed (up to 90%). The effect of the LO inhibitors was not due to non-specific interference with intracellular radical intermediates, because AA861 and ETYA showed no radical scavenging activity. Two PKC inhibitors, H-7 and H-8, similarly suppressed lymphocyte proliferation and showed essentially the same suppressive pattern as LO inhibitors. The results clearly indicate that LO product(s) participate in signal transduction mechanisms in T lymphocytes, possibly via stimulation of PKC activity and cell proliferation.

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Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jian-Ming LüChangyi Chen
Apr 17, 1999·Metabolism: Clinical and Experimental·M S GowriS Azhar
May 9, 2007·Immunology·Jeanne M Cook-MoreauMichel A Rigaud
Nov 4, 2000·Expert Opinion on Investigational Drugs·V E SteeleG J Kelloff
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M UsamiA Miki
Jul 18, 2000·American Journal of Physiology. Cell Physiology·K P TewariJ Cuppoletti
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