PMID: 6113615Feb 1, 1981Paper

Lipoxygenase pathway and hydroperoxy acids: possible relevance to aspirin-induced asthma and hyperirritability of airways in asthmatics

Prostaglandins and Medicine
N Chand, B M Altura

Abstract

The precise mechanisms(s) responsible for airway hyperreactivity to spasmogenic agents (for example, cholinergic stimulants, alpha-adrenergic agonists, histamine, PGF2 alpha and several other nonspecific stimuli) in asthmatics is not known. Substantial evidence exists fo the mediator, as well as modulatory, roles of the products of arachidonic acid metabolism operating via the cyclo-oxygenase pathway in the pathophysiology of lung diseases. Aspirin and other inhibitors of cyclo-oxygenase induce severe bronchospasm and asthmatic attacks in a significant population of asthmatic patients. This adverse effect of aspirin is often attributed to inhibition of the synthesis and release of defensive "modulatory" endogenous prostaglandins (PGD and PGI2?) in the lungs. Thus, removal of their "negative feedback" mechanism on the allergic release of chemical mediators (e.g., histamine and SRS-A: leukotriene C and D) from lung mast cells could lead to an enhancement of the release of mediators and severity of asthmatic attacks. In addition to these mechanisms, recent work suggests the diversion of arachidonic acid (AA) metabolism via the lipoxygenase pathway (especially after cyclo-oxygenase inhibition by aspirin and indomethacin), thereby l...Continue Reading

References

Feb 1, 1975·The Journal of Pharmacy and Pharmacology·L GrodzinskaR J Gryglewski
Jun 1, 1977·The Journal of Allergy and Clinical Immunology·J OrehekJ Charpin
Sep 19, 1973·Nature: New Biology·J OrehekA Bouhuys
Jun 1, 1980·Prostaglandins·P J Gardiner, H O Collier
Jun 1, 1980·British Journal of Pharmacology·J J Adcock, L G Garland
Jul 1, 1980·Allergy·B SamuelssonP Borgeat

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