Lippia gracilis essential oil in β-cyclodextrin inclusion complexes: an environmentally safe formulation to control Aedes aegypti larvae

Pest Management Science
Juliana G GalvãoR S Nunes

Abstract

One of the most efficient ways to prevent arboviruses, such as dengue fever, yellow fever, chikungunya and Zika, is by controlling their vector, the Aedes aegypti. Because this vector is becoming resistant to most larvicides used, the development of new larvicides should be considered. β-Cyclodextrin (β-CD) complexes have been investigated as an interesting way of enabling the use of essential oils in water as larvicides. This study comprised the development of Lippia gracilis essential oil (LGEO) and β-CD inclusion complexes for control of Ae. aegypti. Thermal analysis clearly showed the formation of complexes using kneading and co-evaporation methods. Gas chromatography analysis showed that kneading without co-solvent (KW) gave the highest content (∼ 15%) of the LGEO major component. Moreover, KW showed that the complex had a 50% lethal concentration (LC50 ; 33 ppm) lower than that of pure LGEO (39 ppm); in other words, complexing LGEO with β-CD improved the larvicidal activity. In addition, LGEO complexed with β-CD (KW) was not harmful to non-target organisms at the concentrations needed to control Ae. aegypti larvae. The inclusion complex with LGEO was a feasible formulation, being economically viable, easy-to-apply and wit...Continue Reading

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Citations

Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carine S F MarquesPatricia Severino
Mar 11, 2020·Frontiers in Bioengineering and Biotechnology·Estefânia Vangelie Ramos CamposLeonardo Fernandes Fraceto
Jul 10, 2021·PloS One·Alex Bruno Lobato RodriguesSheylla Susan Moreira da Silva de Almeida
Sep 22, 2020·Acta Tropica·Tássio Rômulo Silva Araújo LuzDenise Fernandes Coutinho

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