Liquid biopsies: Potential and challenges.

International Journal of Cancer. Journal International Du Cancer
Isabel HeidrichKlaus Pantel

Abstract

The analysis of tumor cells or tumor cell products obtained from blood or other body fluids ("liquid biopsy" [LB]) provides a broad range of opportunities in the field of oncology. Clinical application areas include early detection of cancer or tumor recurrence, individual risk assessment and therapy monitoring. LB allows to portray the entire disease as tumor cells or tumor cell products are released from all metastatic or primary tumor sites, providing comprehensive and real-time information on tumor cell evolution, therapeutic targets and mechanisms of resistance to therapy. Here, we focus on the most prominent LB markers, circulating tumor cells (CTCs) and circulating tumor-derived DNA (ctDNA), in the blood of patients with breast, prostate, lung and colorectal cancer, as the four most frequent tumor types in Europe. After a brief introduction of key technologies used to detect CTCs and ctDNA, we discuss recent clinical studies on these biomarkers for early detection and prognostication of cancer as well as prediction and monitoring of cancer therapies. We also point out current methodological and biological limitations that still hamper the implementation of LB into clinical practice.

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Citations

Dec 17, 2020·International Journal of Molecular Sciences·Marta Tellez-GabrielMaria Perander
Jan 13, 2021·Biomedicines·Patricia Mondelo-MacíaRoberto Díaz-Peña
Apr 14, 2021·Seminars in Cancer Biology·Pietro AndreiAlberto Bardelli
Apr 26, 2021·Oncology and Therapy·Snehal B PatelJean R Lopategui
May 11, 2021·Molecular Oncology·Martyna Filipska, Rafael Rosell
Jun 3, 2021·Journal of Personalized Medicine·Miriam González-CondeClotilde Costa
Jun 10, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bo-Wei HanYing-Song Wu
Jun 29, 2021·The International Journal of Biochemistry & Cell Biology·Kuen Kuen LamPeh Yean Cheah
Jul 12, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christian RolfoDavid Gandara
Oct 11, 2021·Annals of Surgical Oncology·Hirotoshi Kikuchi, Hiroya Takeuchi
Oct 28, 2021·Future Oncology·Ullas BatraAnurag Mehta
Aug 25, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manuela KrumbholzMarkus Metzler

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