Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach

The EPMA Journal
Olga GolubnitschajaLeonard Berliner

Abstract

The annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas. Given the increased incidence of both primary and metastatic liver cancers, a new, revised approach is needed to advance medical care based on predictive diagnostics, innovative screening programmes, targeted preventive measures, and patient stratification for treatment algorithms tailored to individualised patient profile. The current pilot study took advantage of systemic alterations characteristic for liver malignancies, utilising liquid biopsy (blood samples) and specific biomarker patterns detected. Key molecular pathways relevant for pathomechanisms of liver cancers have been considered opening a perspective for both-individualised diagnostics and targeted treatment. Systemic alterations have been analysed prior to the therapy...Continue Reading

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Citations

Dec 11, 2019·International Journal of Environmental Research and Public Health·Elvin T NgRoger C Ho
Jul 2, 2020·Biomarkers in Medicine·Serdar SaridemirLütfi Doğan
Aug 29, 2020·Journal of Clinical Medicine·Alena LiskovaOlga Golubnitschaja
Aug 30, 2020·Cancers·Lenka KoklesovaPeter Kubatka
Jan 21, 2021·Biomarkers in Medicine·Xin-Fei XuTian Yang

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Methods Mentioned

BETA
biopsies
biopsy
blood draw
electrophoresis

Software Mentioned

Quantity One
Adobe Photoshop
SPSS

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