Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri

International Journal of Molecular Sciences
D DvorskáZuzana Danková

Abstract

Utilization of liquid biopsy in the management of cancerous diseases is becoming more attractive. This method can overcome typical limitations of tissue biopsies, especially invasiveness, no repeatability, and the inability to monitor responses to medication during treatment as well as condition during follow-up. Liquid biopsy also provides greater possibility of early prediction of cancer presence. Corpus uteri mesenchymal tumors are comprised of benign variants, which are mostly leiomyomas, but also a heterogenous group of malignant sarcomas. Pre-surgical differentiation between these tumors is very difficult and the final description of tumor characteristics usually requires excision and histological examination. The leiomyomas and malignant leiomyosarcomas are especially difficult to distinguish and can, therefore, be easily misdiagnosed. Because of the very aggressive character of sarcomas, liquid biopsy based on early diagnosis and differentiation of these tumors would be extremely helpful. Moreover, after excision of the tumor, liquid biopsy can contribute to an increased knowledge of sarcoma behavior at the molecular level, especially on the formation of metastases which is still not well understood. In this review, we ...Continue Reading

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Citations

Nov 14, 2019·International Journal of Molecular Sciences·Balint Nagy
Jan 31, 2020·Current Oncology Reports·Christine De BruynAn Coosemans
Apr 30, 2020·International Journal of Molecular Sciences·Michał CiebieraArtur Czekierdowski
Oct 31, 2020·Frontiers in Oncology·Ya-Ling LiBing Song
Aug 28, 2021·International Journal of Molecular Sciences·Anna TestaMaria Felice Brizzi

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Methods Mentioned

BETA
biopsy
lavage
biopsies
PCR
chromosomal aberrations

Software Mentioned

CellSieve
STUMP

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