Liquid biopsy for lung cancer early detection

Journal of Thoracic Disease
Mariacarmela SantarpiaRafael Rosell

Abstract

Molecularly targeted therapies and immune checkpoint inhibitors have markedly improved the therapeutic management of advanced lung cancer. However, it still remains the leading cause of cancer-related mortality worldwide, with disease stage at diagnosis representing the main prognostic factor. Detection of lung cancer at an earlier stage of disease, potentially susceptible of curative resection, can be critical to improve patients survival. Low-dose computed tomography (LDCT) screening of high-risk patients has been demonstrated to reduce mortality from lung cancer, but can be also associated with high false-positive rate, thus often resulting in unnecessary interventions for patients. Novel sensitive and specific biomarkers for identification of high-risk subjects and early detection that can be used alternatively and/or complement current routine diagnostic procedures are needed. Liquid biopsy has recently demonstrated its clinical usefulness in advanced NSCLC as a surrogate of tissue biopsy for noninvasive assessment of specific genomic alterations, thereby providing prognostic and predictive information. Different biosources from liquid biopsy, including cell free circulating tumor DNA (ctDNA), circulating tumor cells (CTCs...Continue Reading

Citations

Feb 15, 2019·Cancers·Jonathan BenzaquenPaul Hofman
Apr 13, 2019·Expert Review of Molecular Diagnostics·Pravin ShendeR S Gaud
Jul 2, 2020·International Journal of Molecular Sciences·Katarzyna WadowskaMariola Śliwińska-Mossoń
Oct 11, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P GarridoF López-Ríos
Jul 11, 2020·Biological Trace Element Research·Piotr BaszukMarcin R Lener
May 29, 2020·Journal of Pathology and Translational Medicine·Sunhee ChangWan Seop Kim
Nov 30, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Marcin R LenerJan Lubiński
Nov 20, 2020·Journal of Clinical Medicine·D AkhoundovaA Curioni-Fontecedro
Mar 4, 2021·Future Oncology·Asrar AlamSujata Pathak
Mar 9, 2021·The Journal of International Medical Research·Qingtao ZhaoXiaopeng Zhang
Apr 4, 2021·Cancers·Mateusz Smolarz, Piotr Widlak
Oct 14, 2020·Critical Reviews in Oncology/hematology·Luciana Santos PessoaValéria Pereira Ferrer
May 1, 2021·International Journal of Molecular Sciences·Daniela FerreiraRaquel Chaves
May 8, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Rajesh VenkataramAnirban Chakraborty
May 25, 2021·Frontiers in Oncology·Radouane El AyachyJean Emmanuel Bibault

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

© 2022 Meta ULC. All rights reserved