Mar 14, 2020

Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors

Epigenetics Insights
Seyed Mohammad Kazem AghamirFatemeh Khatami

Abstract

Blood test is a kind of liquid biopsy that checks cancer cells or cancer nucleic acids circulating freely from cells in the blood. A liquid biopsy may be used to distinguish cancer at early stages and it could be a game-changer for both cancer diagnosis and prognosis strategies. Liquid biopsy tests consider several tumor components, such as DNA, RNA, proteins, and the tiny vesicles originating from tumor cells. Actually, liquid biopsy signifies the genetic alterations of tumors through nucleic acids or cells in various body fluids, including blood, urine, cerebrospinal fluid, or saliva in a noninvasive manner. In this review, we present an overall description of liquid biopsy in which circulating tumor cells, cell-free nucleic acids, exosomes, and extrachromosomal circular DNA are included.

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Mentioned in this Paper

Blood
Biopsy of Testis
Body Fluids
Nucleic Acids
Exosomes
DNA
Neoplastic Cell
Neoplasms
Tumor Cells, Malignant
Noninvasive

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