Liquid biopsy: will it be the 'magic tool' for monitoring response of solid tumors to anticancer therapies?

Current Opinion in Oncology
Isabelle GingrasMichail Ignatiadis

Abstract

The aim of this review is to highlight the recent advances (in the past 12 months) concerning circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in oncology. The value of CTCs as a prognostic biomarker is now well validated in breast, colon, and prostate cancer, but no trial has yet demonstrated that modifying treatment according to CTCs is superior to standard of care. Ongoing trials are addressing the clinical utility of CTCs. Moreover, there is emerging evidence about the potential of CTCs as a tumor tissue source to analyze protein and RNA expression, DNA mutations and drug sensitivity. ctDNA is a specific biomarker associated with tumor burden, and small studies have shown an association with worse outcome; prospective clinical studies on the prognostic and predictive value of ctDNA are needed. ctDNA can be used for tumor molecular profiling, with the potential advantage to encompass the spectrum of mutations present in the tumor. CTCs and ctDNA are promising new biomarkers in oncology, with potential clinical applications for monitoring and for comprehensive molecular profiling of cancer. For each assay, demonstration of analytical and clinical validity, as well as clinical utility in prospective clinical tr...Continue Reading

References

Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel F HayesLeon W W M Terstappen
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J CohenNeal J Meropol
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoDerek Raghavan
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkAndrés M Poveda
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew G KrebsFiona H Blackhall
Sep 13, 2011·PloS One·Florent MouliereAlain R Thierry
Jun 1, 2012·Science Translational Medicine·Tim ForshewNitzan Rosenfeld
Dec 1, 2012·Science Translational Medicine·Rebecca J LearyVictor E Velculescu
Feb 15, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·N MöckelmannR Knecht
Mar 1, 2013·International Journal of Cancer. Journal International Du Cancer·Kjersti TjensvollRune Smaaland
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
May 17, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F C BidardP Hammel
Sep 10, 2013·Clinical Colorectal Cancer·Javier SastreUNKNOWN Spanish Cooperative Group for the Treatment of Digestive Tumors
Nov 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lu HanQicheng Zhao
Jan 22, 2014·Nature Reviews. Clinical Oncology·Matthew G KrebsCaroline Dive
Feb 8, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia A BeaverBen Ho Park
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Daniel L AdamsMassimo Cristofanilli
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
Feb 25, 2014·Neoplasia : an International Journal for Oncology Research·John A MartignettiPeter Dottino
Mar 1, 2014·Nature Protocols·Nezihi Murat KarabacakMehmet Toner
Mar 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amir GoldkornNicholas J Vogelzang
Mar 25, 2014·International Journal of Cancer. Journal International Du Cancer·Karen-Lise Garm SpindlerAnders Jakobsen
Apr 25, 2014·Breast Cancer Research : BCR·Michail IgnatiadisKlaus Pantel
Apr 26, 2014·Oncology Letters·Satoshi IgawaNoriyuki Masuda
May 7, 2014·International Journal of Cancer. Journal International Du Cancer·Karen-Lise Garm SpindlerAnders Jakobsen
Jun 2, 2014·Nature Medicine·Cassandra L HodgkinsonCaroline Dive
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey B SmerageDaniel F Hayes
Jul 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L De Mattos-ArrudaJ S Reis-Filho
Aug 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jean-Yves DouillardRose McCormack
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Lei MaPing Li
Aug 27, 2014·Nature Reviews. Cancer·Catherine Alix-Panabières, Klaus Pantel
Sep 4, 2014·The New England Journal of Medicine·Emmanuel S AntonarakisJun Luo
Sep 4, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RothéM Ignatiadis
Oct 1, 2014·Journal of Gastrointestinal and Liver Diseases : JGLD·Adriana RomitiPaolo Marchetti

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Citations

Dec 15, 2015·Expert Review of Proteomics·Radwa EwaishaKaren S Anderson
May 7, 2016·Nature Medicine·Trever G Bivona, Robert C Doebele
Apr 16, 2019·Genetic Testing and Molecular Biomarkers·Jianxia ChenRuihuan Xu
Sep 25, 2019·Nature Reviews. Disease Primers·Nadia HarbeckFatima Cardoso
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Alessia GrassoF Vilella
Apr 27, 2019·Frontiers in Oncology·Matteo SantoniRodolfo Montironi
Sep 10, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Tomasz KolendaKatarzyna Lamperska

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Methods Mentioned

BETA
biopsy
biopsies

Clinical Trials Mentioned

NCT01701050
NCT02137837

Software Mentioned

CellSearch

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