Liquid chromatographic analysis of penem antibiotic FCE22101 in biological fluids with a liquid-liquid extraction procedure

Journal of Chromatography. B, Biomedical Applications
M MatsuokaT Sato

Abstract

A sensitive high-performance liquid chromatographic method has been developed for the determination of penem antibiotic FCE22101 in plasma and urine. FCE22101 was extracted from plasma and urine with ethyl acetate. After evaporating, the sample solutions were analyzed by a reversed-phase high-performance liquid chromatographic system using a two-sided bracketing injection technique. The determination limit of FCE22101 was 5 ng/ml in plasma. Analysis of the spiked plasma samples demonstrated the good accuracy and precision of the method. The proposed method improved from five- to ten-fold on the analytical sensitivity in comparison with the most commonly ultrafiltration method.

References

Jun 1, 1990·Antimicrobial Agents and Chemotherapy·A SaathoffP Koeppe
Mar 1, 1990·The Journal of Antimicrobial Chemotherapy·G VinçonM Strolin Benedetti
Mar 1, 1989·The Journal of Antimicrobial Chemotherapy·G FranceschiC Della Bruna

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