PMID: 2093388Jan 1, 1990Paper

Liquid chromatographic determination of ivermectin in animal plasma with trifluoroacetic anhydride and N-methylimidazole as the derivatization reagent

Journal of Pharmaceutical and Biomedical Analysis
P de MontignyJ V Pivnichny

Abstract

Ivermectin is a potent anthelmintic agent which was detected at low concentrations in cattle plasma by LC after conversion to a fluorescent derivative. This was accomplished by reaction with acetic anhydride (AA) and pyridine for 24 h at 100 degrees C or with AA and N-methylimidazole (NMIM) for 1 h at 95 degrees C. Substituting trifluoroacetic anhydride (TFAA) for AA reduced the reaction time to less than 30 s at 25 degrees C, yielding an intensely fluorescent derivative with substantially fewer reagent by-products. The need for further sample preparation after derivatization with TFAA-NMIM was thereby eliminated, and detection limits of less than 20 pg ml-1 ivermectin could be achieved with 1 ml of plasma by a considerably simpler analytical procedure.

References

Jul 1, 1973·The Journal of Pathology·D A Fleming, I Morrice
Jun 1, 1982·Journal of Medicinal Chemistry·H MrozikD A Ostlind
Jul 1, 1985·Parasitology Today·W C Campbell

❮ Previous
Next ❯

Citations

Mar 1, 1997·Biomedical Chromatography : BMC·D W FinkJ S Shim
Nov 17, 2006·Analytical and Bioanalytical Chemistry·Nevenka Kozuh ErzenVesna Cerkvenik-Flajs
Oct 11, 2005·Ecotoxicology·Nevenka Kozuh ErzenMilan Pogacnik
Mar 30, 2006·Ecotoxicology·Vlasta JencicVesna Cerkvenik-Flajs
Jun 3, 2006·Ecotoxicology·Tatjana Tisler, Nevenka Kozuh Erzen
Jan 30, 2007·Veterinary Research Communications·T Bengone NdongM Alvinerie
Jun 1, 1993·Veterinary Parasitology·R HerdK Wardhaugh
Nov 8, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Na-BangchangJ Lazdins
Jan 30, 2004·Veterinary Parasitology·A LifschitzC Lanusse
Jan 26, 2002·Veterinary Parasitology·V CerkvenikM Pogacnik
Dec 24, 1997·Veterinary Parasitology·P L ToutainM E McKenzie
Mar 20, 2003·Journal of Pharmaceutical and Biomedical Analysis·J G PrietoA I Alvarez
Oct 20, 1998·Journal of Pharmaceutical and Biomedical Analysis·L AntonianP G Wislocki
Apr 18, 2002·Biosensors & Bioelectronics·Jeanne V SamsonovaChristopher T Elliott
Apr 22, 1999·Journal of Veterinary Pharmacology and Therapeutics·A LifschitzC Lanusse
Apr 4, 2000·Journal of Veterinary Pharmacology and Therapeutics·A H Atta, M N Abo-Shihada
May 10, 2002·Journal of Veterinary Pharmacology and Therapeutics·A LifschitzC Lanusse
Mar 19, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L MorenoC Lanusse
Aug 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·M A NowakowskiR M Jones
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Tanya H BurkholderDawn Boothe
Apr 17, 2009·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·A Rae GandolfC Lanusse
Jan 24, 2014·TheScientificWorldJournal·Konrad Pietruk, Piotr Jedziniak
Oct 7, 2008·Research in Veterinary Science·Somsmorn ChittrakarnSuwich Thammapalo
Nov 11, 2015·Journal of Agricultural and Food Chemistry·Laura MorenoLuis Alvarez
Jan 5, 2011·Journal of Veterinary Pharmacology and Therapeutics·D ZeleI Grabnar
Sep 8, 2011·Journal of Veterinary Pharmacology and Therapeutics·C GokbulutM Boyacioglu
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·F ImperialeC Lanusse
Nov 3, 2016·Journal of Veterinary Pharmacology and Therapeutics·C GokbulutV Y Cirak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.