Liquid chromatographic-thermospray tandem mass spectrometric quantitative analysis of some drugs with hypnotic, sedative and tranquillising properties in whole blood

Journal of Chromatography. B, Biomedical Applications
A M VerweijP J Lipman

Abstract

Results are presented of a liquid chromatographic-thermospray tandem mass spectrometric method of analysing different drugs in whole blood. Substances with hypnotic, sedative and tranquillising properties from the benzodiazepine, the thioxanthene, the butyrophenone, the methadone and the diphenylbutylpiperidine groups were investigated. It appears that ten to hundred times lower detection limits for the substances in whole blood can be reached with this method compared with methods more commonly used. Detection limits in the range 10-100 pg per injection (equivalent to 0.05-0.5 ng/ml whole blood) were reached for the majority of the compounds.

References

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Citations

Sep 15, 2000·Mass Spectrometry Reviews·J F Van BocxlaerA P De Leenheer
May 18, 2000·Journal of Pharmaceutical and Biomedical Analysis·I A ShehataF Belal
Mar 23, 2002·Journal of the American Society for Mass Spectrometry·Tetsuya ArinobuOsamu Suzuki
Jul 20, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Tetsuya ArinobuHiroshi Seno
Dec 16, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·F Musshoff, B Madea
Jul 1, 2009·Bioanalysis·Victoria F SamanidouIoannis N Papadoyannis
Dec 28, 2005·Journal of Pharmaceutical and Biomedical Analysis·Xiao-Pen LeeKeizo Sato
Aug 12, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ryh-Nan PanLi-Heng Pao
Jan 30, 2002·Journal of Pharmaceutical and Biomedical Analysis·M M Hefnawy
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Antonella ArestaCarlo Giorgio Zambonin
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M J Bogusz

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