Liquid chromatography coupled to tandem mass spectrometry for the residue determination of ethylenethiourea (ETU) and propylenethiourea (PTU) in water

Journal of Chromatography. a
Cristina RipollésFélix Hernández

Abstract

Ethylenethiourea (ETU) and propylenethiourea (PTU) are the main degradation products of dithiocarbamates fungicides, which are widely used in agriculture from several years ago. Their determination in water at low concentrations (e.g. sub-ppb levels) is highly problematic due to their polar character and low molecular size. In the present study, two analytical methodologies have been developed and compared for the selective and sensitive determination of ETU and PTU in various types of waters. Both approaches are based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with electrospray ionization, using triple quadrupole analyzer. Whereas the first methodology used an on-line solid-phase extraction (SPE) step in order to reach the adequate sensitivity, the second one avoided sample treatment and was based on direct injection into an ultra high performance liquid chromatography (UHPLC-MS/MS) system, making use of a new-generation instrument in order to reach sub-ppb analyte levels in water. Strong matrix effects (typically leading to signal enhancement) were observed for most of the evaluated waters, especially when applying the on-line SPE method, surely due to the higher amount of sample injected into the...Continue Reading

References

Apr 21, 2001·Journal of Agricultural and Food Chemistry·S KontouC Tzia
Jun 11, 2002·Journal of Analytical Toxicology·Ikram Debbarh, Nicholas Moore
Jun 25, 2005·Journal of Analytical Toxicology·Souleiman El BalkhiMartine Galliot-Guilley
Jul 13, 2006·Journal of Mass Spectrometry : JMS·José M MarínFélix Hernández
Jul 9, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Gül Ozhan, Buket Alpertunga
May 15, 2009·Rapid Communications in Mass Spectrometry : RCM·Cristina RipollésFélix Hernández

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Citations

Jan 11, 2014·Environmental Science and Pollution Research International·Emma Gracia-LorFélix Hernández
Nov 14, 2014·Critical Reviews in Analytical Chemistry·Cláudia RibeiroMaria Elizabeth Tiritan
Nov 15, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Lukas VaclavikKaterina Mastovska
Sep 22, 2021·Journal of Agricultural and Food Chemistry·Rosselei Caiel da SilvaAndré de Kok

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