Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements

Journal of Separation Science
Yongqiang Liu, Navindra P Seeram

Abstract

Pomegranate (Punica granatum L.) fruit and flower extracts, which are rich sources of bioactive phenolics, are widely utilized as ingredients in botanical dietary supplements. While the phenolic characterization of extracts of pomegranate fruit has been previously studied by liquid chromatography with tandem mass spectrometry, there is lack of similar data for pomegranate flowers. Herein, liquid chromatography with time-of-flight tandem mass spectrometry was utilized to comprehensively characterize the phenolics present in two pomegranate extracts, previously studied for their in vitro and in vivo biological effects, namely, a patented commercial pomegranate fruit extract (Pomella®), and a pomegranate flower extract. Seventy-one phenolics were characterized in the pomegranate fruit extract with the vast majority identified in the flower extract. However, only the pomegranate fruit extract contained tannin-glucuronides and two punicalagin isomers (a characteristic pomegranate phenolic) were identified in this extract while four were identified in the flower extract. The previously reported compounds, pomellatannin and punicatannins A/B, were identified as unique chemical markers in the pomegranate fruit and flower extracts, resp...Continue Reading

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Citations

Jun 6, 2019·Frontiers in Plant Science·Irit Bar-Ya'akovDoron Holland
Apr 7, 2020·Current Pharmaceutical Design·Nathalie T B DelgadoRoger L Dos Santos
Jun 30, 2019·Journal of Ethnopharmacology·Paulo Vitor Moreira RomãoArquimedes Gasparotto Junior
Oct 10, 2021·Journal of the Science of Food and Agriculture·Han LüWeilin Li

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