Liquid chromatography-electrospray ionisation-mass spectrometry based method for the simultaneous determination of algal and cyanobacterial toxins in phytoplankton from marine waters and lakes followed by tentative structural elucidation of microcystins

Journal of Chromatography. a
Jens DahlmannBernd Luckas

Abstract

A liquid chromatography (LC)-based method with mass spectrometric (MS) detection was developed for simultaneous determination of various algal and cyanobacterial toxins extracted from phytoplankton occurring world-wide in marine waters and lakes. The method enables quantification of saxitoxin, anatoxin-A, domoic acid, nodularin, microcystins, okadaic acid and dinophysistoxin-1 with a single chromatographic run. In addition, the applied chromatographic conditions allow isolation and identification of substances suspected to be "new" microcystins (cyclic peptides) by fraction collection, hydrolysis, derivatisation of resulting free amino acids with the modified chiral Marfey's reagent N-alpha-(2,4-dinitro-5-fluorophenyl)-L-valinamide (L-FDVA) and enantioselective analysis of the amino acid derivatives by LC-ESI-MS.

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Citations

Dec 18, 2007·Analytical and Bioanalytical Chemistry·Bernd Christian, Bernd Luckas
Mar 20, 2010·Analytical and Bioanalytical Chemistry·Rómulo AráozJordi Molgó
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Felipe A DörrDietrich A Volmer
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Jul 28, 2012·Journal of Chromatography. a·István IliszAntal Péter
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Apr 20, 2010·Toxicon : Official Journal of the International Society on Toxinology·Anja Peuthert, Stephan Pflugmacher
Nov 3, 2009·Toxicon : Official Journal of the International Society on Toxinology·Stuart A OehrleJudy Westrick
Sep 15, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bo YangYuan Jiang
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