Liquid chromatography-high resolution mass spectrometric methods for the surveillance monitoring of cyanotoxins in freshwaters

Talanta
Sara BogialliPaolo Pastore

Abstract

A comprehensive risk management on human exposure to cyanotoxins, whose production is actually unpredictable, is limited by reliable analytical tools for monitoring as many toxic algal metabolites as possible. Two analytical approaches based on a LC-QTOF system for target analysis and suspect screening of cyanotoxins in freshwater were presented. A database with 369 compounds belonging to cyanobacterial metabolites was developed and used for a retrospective data analysis based on high resolution mass spectrometry (HRMS). HRMS fragmentation of the suspect cyanotoxin precursor ions was subsequently performed for correctly identifying the specific variants. Alternatively, an automatic tandem HRMS analysis tailored for cyanotoxins was performed in a single chromatographic run, using the developed database as a preferred precursor ions list. Twenty-five extracts of surface and drinking waters contaminated by cyanobacteria were processed. The identification of seven uncommon microcystins (M(O)R, MC-FR, MSer7-YR, D-Asp3MSer7-LR, MSer7-LR, dmAdda-LR and dmAdda-YR) and 6 anabaenopeptins (A, B, F, MM850, MM864, oscyllamide Y) was reported. Several isobaric variants, fully separated by chromatography, were pointed out. The developed metho...Continue Reading

Citations

Jan 18, 2019·Annual Review of Food Science and Technology·Bing ShaoYongning Wu
Jul 15, 2020·Journal of Biochemical and Molecular Toxicology·Piyush KumarSanjay Kumar
Feb 25, 2021·Mass Spectrometry Reviews·Debabrata PandaGrzegorz Boczkaj
Apr 30, 2021·Analytical Methods : Advancing Methods and Applications·B González-GayaO Zuloaga
Apr 18, 2020·Environmental Science & Technology·Regiane Natumi, Elisabeth M-L Janssen

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