PMID: 11929273Apr 4, 2002Paper

Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce

Journal of Agricultural and Food Chemistry
Richard B van BreemenRoohollah Sharifi

Abstract

Several epidemiological studies suggest a lower incidence of prostate cancer in men who routinely consume tomato products. Tomatoes are the primary dietary source of lycopene, which is among the most potent antioxidants of the carotenoids. Men with clinical stage T1 or T2 prostate adenocarcinoma were recruited (n = 32) and consumed tomato sauce based pasta dishes for 3 weeks (equivalent to 30 mg of lycopene per day) before radical prostectomy. Prostate tissue from needle biopsy just before intervention and prostectomy after supplementation from a subset of 11 subjects was evaluated for both total lycopene and lycopene geometrical isomer ratios. A gradient HPLC system using a C(18) column with UV-vis absorbance detection was used to measure total lycopene. Because the absorbance detector was insufficiently sensitive, HPLC with a C(30) column and positive ion atmospheric pressure chemical ionization mass spectrometric (LC-MS) detection was developed as a new assay to measure the ratio of lycopene cis/trans isomers in these samples. The limit of detection of the LC-MS method was determined to be 0.93 pmol of lycopene on-column, and a linear response was obtained over 3 orders of magnitude. Total lycopene in serum increased 2.0-fol...Continue Reading

References

Jan 1, 1997·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo
Jan 7, 2000·Free Radical Research·D E HollowayP M Bramley
Apr 8, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·O FroescheisJ Bausch
Jul 13, 2000·Journal of Chromatography. a·L C SanderM Pursch
Oct 29, 2000·Journal of Agricultural and Food Chemistry·L K HenryS J Schwartz
Jan 1, 1959·Experimental Cell Research·A FORSSBERGO LINDBERG

❮ Previous
Next ❯

Citations

Sep 27, 2003·Phytochemical Analysis : PCA
Mar 31, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M V VertzoniH A Archontaki
Jul 21, 2007·The British Journal of Nutrition·Karin JacobGaspar Ros Berruezo
Oct 2, 2012·Journal of Agricultural and Food Chemistry·Matthias FrommReinhold Carle
Mar 17, 2007·Critical Reviews in Food Science and Nutrition·Eun-Sun Hwang, Phyllis E Bowen
Sep 11, 2010·Critical Reviews in Food Science and Nutrition·K K Namitha, P S Negi
Apr 1, 2010·Toxins·Maria RussoGian Luigi Russo
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Thangaiyan Rabi, Sanjay Gupta
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emelia A AssarSassan Hafizi
Oct 4, 2011·Translational Oncology·Jina Kim, Yuri Kim
Jul 1, 2008·Cancer Letters·Richard B van Breemen, Natasa Pajkovic
Jul 15, 2015·Journal of Food Science·Brendon W SmithJohn W Erdman
May 19, 2012·International Journal of Molecular Sciences·Cristiano LongoAntonella Leone
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masaki HondaMotonobu Goto
Nov 17, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angelika HerzogKarin Wertz
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Nadine MüllerPeter Stehle
Nov 11, 2003·The Journal of Nutrition·Ute C Obermüller-JevicLester Packer
Sep 2, 2003·The Journal of Nutrition·Peter J KorytkoBarry S Levine
Dec 1, 2004·The Journal of Nutrition·Jessica K CampbellJohn W Erdman
Apr 18, 2013·Cancer Prevention Research·Krystle E ZunigaJohn W Erdman
Nov 24, 2006·Molecular Cancer Therapeutics·Ang LiuRichard B van Breemen
Sep 15, 2019·International Journal of Biological Macromolecules·S BagheriT Haertlé
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hidde P van SteenwijkAlie de Boer
Jul 23, 2021·Critical Reviews in Food Science and Nutrition·Sarah JamiesonAnupam Bishayee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.