Liquid-crystalline aromatic-aliphatic copolyester bioresorbable polymers

Biomaterials
Horacio Montes de OcaJohn W Goodby

Abstract

The synthesis and characterisation of a series of liquid-crystalline aromatic-aliphatic copolyesters are presented. Differential scanning calorimetry showed these polymers have a glass transition temperature in the range 72 degrees C-116 degrees C. Polarised optical microscopy showed each polymer exhibits a nematic mesophase on heating to the molten state at temperatures below 165 degrees C. Melt processing is demonstrated by the production of injection moulded and compression moulded specimens with Young's modulus of 5.7 +/- 0.3 GPa and 2.3 +/- 0.3 GPa, respectively. Wide-angle X-ray scattering data showed molecular orientation is responsible for the increase of mechanical properties along the injection direction. Degradation studies in the temperature range 37 degrees C-80 degrees C are presented for one polymer of this series and a kinetic constant of 0.002 days(-1) is obtained at 37 degrees C assuming a first order reaction. The activation energy (83.4 kJ mol(-1)) is obtained following the Arrhenius analysis of degradation, showing degradation of this material is less temperature sensitive compared with other commercially available biodegradable polyesters. In vitro and in vivo biocompatibility data are presented and it is ...Continue Reading

Citations

Jan 1, 2014·International Scholarly Research Notices·Narendran Kandaswamy, Nanthini Raveendiran
Oct 27, 2015·Macromolecular Rapid Communications·Audrey LlevotHenri Cramail
Feb 15, 2018·Beilstein Journal of Nanotechnology·Baeckkyoung Sung, Min-Ho Kim
Oct 17, 2019·Polymers·Alexandra ZamboulisGeorge Z Papageorgiou
Sep 22, 2020·ACS Sustainable Chemistry & Engineering·Gijs W de KortCarolus H R M Wilsens

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