Liquid Crystalline Nanostructures as PEGylated Reservoirs of Omega-3 Polyunsaturated Fatty Acids: Structural Insights toward Delivery Formulations against Neurodegenerative Disorders

ACS Omega
Angelina AngelovaBorislav Angelov

Abstract

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are bioactive lipids with considerable impact in medicine and nutrition. These compounds exert structuring effects on the cellular membrane organization, regulate the gene expression, and modulate various signaling cascades and metabolic processes. The purpose of the present work is to demonstrate the structural features of ω-3 PUFA-containing three-dimensional supramolecular lipid assemblies suitable for pharmaceutical applications that require soft porous carriers. We investigate the liquid crystalline structures formed upon mixing of eicosapentaenoic acid (EPA, 20:5) with the lyotropic nonlamellar lipid monoolein and the formation of multicompartment assemblies. Starting with the monoolein-based lipid cubic phase, double membrane vesicles, cubosome precursors, sponge-type particles (spongosomes), mixed intermediate nonlamellar structures, and multicompartment assemblies are obtained through self-assembly at different amphiphilic compositions. The dispersions containing spongosomes as well as nanocarriers with oil and vesicular compartments are stabilized by PEGylation of the lipid/water interfaces using a phospholipid with a poly(ethylene glycol) chain. The microstructures of t...Continue Reading

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Citations

Jun 6, 2019·Physical Chemistry Chemical Physics : PCCP·Anan YaghmurWinnie Edith Svendsen
Sep 26, 2019·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralKhondkar Siddique-E-Rabbani
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Feb 20, 2019·International Journal of Molecular Sciences·Hyun-Jong JangKyung-Ok Cho
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Hadis RostamabadiSeid Mahdi Jafari
Dec 31, 2020·International Journal of Molecular Sciences·Umair ShabbirDeog-Hwan Oh
Jun 1, 2021·Journal of Colloid and Interface Science·Saffron J BryantKaren J Edler
Jul 13, 2021·European Journal of Pharmacology·Min JiaYulong Chen
Jan 29, 2022·Journal of Agricultural and Food Chemistry·Chen TanSeid Mahdi Jafari

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
light optical microscopy
light scattering
Bragg diffraction

Software Mentioned

PRIMUS

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