Liquid Embolic Agents for Endovascular Embolization: Evaluation of an Established (Onyx) and a Novel (PHIL) Embolic Agent in an In Vitro AVM Model.

AJNR. American Journal of Neuroradiology
D F VollherbstM A Möhlenbruch

Abstract

Embolization plays a key role in the treatment of arteriovenous malformations. The aim of this study was to evaluate an established (Onyx) and a novel (precipitating hydrophobic injectable liquid [PHIL]) liquid embolic agent in an in vitro AVM model. An AVM model was integrated into a circuit system. The artificial nidus (subdivided into 28 honeycomb-like sections) was embolized with Onyx 18 (group Onyx; n = 8) or PHIL 25 (group PHIL; n = 8) with different pause times between the injections (30 and 60 seconds, n = 4 per study group) by using a 1.3F microcatheter. Procedure times, number of injections, embolization success (defined as the number of filled sections of the artificial nidus), volume of embolic agent, and frequency and extent of reflux and draining vein embolization were assessed. Embolization success was comparable between Onyx and PHIL. Shorter pause times resulted in a significantly higher embolization success for PHIL (median embolization score, 28 versus 18; P = .011). Compared with Onyx, lower volumes of PHIL were required for the same extent of embolization (median volume per section of the artificial nidus, 15.5 versus 3.6 μL; P < .001). While the embolization success was comparable for Onyx and PHIL, pause ...Continue Reading

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Citations

Aug 11, 2018·AJNR. American Journal of Neuroradiology·D F VollherbstM A Möhlenbruch
Feb 15, 2019·Cardiovascular and Interventional Radiology·Dominik F VollherbstChristof M Sommer
Mar 21, 2018·Journal of Neurointerventional Surgery·Dominik F VollherbstMarkus A Möhlenbruch
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jasmine LordAndrew L Lewis
Jul 6, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Dominik F VollherbstMarkus A Möhlenbruch
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Oriane PoupartDominique P Pioletti
Jul 6, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Edgar A SamaniegoSantiago Ortega-Gutierrez
Nov 21, 2020·AJNR. American Journal of Neuroradiology·N SchmittD F Vollherbst
Mar 7, 2021·Journal of Clinical Medicine·Pierleone LucatelliCarlo Catalano
Jun 4, 2021·Neurointervention·Adam A DmytriwPrakash Muthusami
Dec 18, 2021·Science Advances·Boris RivkinOliver G Schmidt

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