Liquid embolisation material reduces the delivered radiation dose: a physical experiment

Acta neurochirurgica
Yuri M Andrade-SouzaMichael L Schwartz

Abstract

To test a new hypothesis that the glue/contrast admixture used for embolisation reduces the dose delivered to AVMs using an experimental model. A model was created using a block of "solid water" (6 x 5 x 2 cm) with twelve wells of different depths. Different concentrations of the glue admixture (Enbucrilate + Lipiodol) were used. The model was irradiated using a 5MV beam with a clinical LINAC system and the dose was checked upstream and downstream. Dose was measured using Kodak XV film, a Vidar 16 bit film scanner and software for therapeutic film dosimetry measurements (RIT software). The radiation dose varied with the distance beyond the glue solid water interface. For distances of 0, 2 and 5 mm to the film, the mean reduction was 13.65% (SD = 2.94), 6.87% (SD = 1.95) and 1.75% (SD = 1.14), respectively. There was also correlation with the Lipiodol concentration in the mixture. The maximum reductions for 80, 50 and 20% Lipiodol concentrations were 16.1% (SD = 1.32), 14.85% (SD = 0.98) and 10% (SD = 1.21), respectively. There was no correlation between the glue depth and the dose delivered. The hypothesis that the glue mixture used for embolisation reduces the radiation dose delivered was experimentally confirmed with this study.

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Citations

Jan 24, 2012·Journal of Neurosurgery·Ching-Hsiao ChengJason P Sheehan
Apr 19, 2011·Journal of Neurosurgery·Maria Mamalui-HunterRobert E Drzymala
May 29, 2012·Journal of Neurosurgery·Jason Sheehan, Chun Po Yen
Nov 7, 2012·Medical Physics·Donald A RobertsAditya S Pandey
Sep 2, 2014·Neurosurgical Focus·Kenan AlKhaliliPascal Jabbour
Jun 4, 2014·Japanese Journal of Radiology·Yoshito TakeuchiUNKNOWN Committee of Practice Guidelines of the Japanese Society of Interventional Radiology
Jul 6, 2014·Neurosurgery Clinics of North America·Matthew R SanbornFelipe C Albuquerque
Dec 24, 2011·AJNR. American Journal of Neuroradiology·F BingA Weill
Nov 7, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Olga Olinca Galván de la CruzMiguel Angel Celis
Jan 8, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Or Cohen-InbarJason P Sheehan
Aug 23, 2012·Clinical Neurology and Neurosurgery·Bradley A GrossRose Du
Apr 18, 2015·Surgical Neurology International·Andrew CongerAaron A Cohen-Gadol
Jan 1, 2015·Nature Reviews. Disease Primers·Michael T LawtonRobert F Spetzler
Feb 6, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Adam A DmytriwRonit Agid
Jun 24, 2017·Stroke; a Journal of Cerebral Circulation·Colin P DerdeynUNKNOWN American Heart Association Stroke Council
Jan 10, 2014·Neurosurgery·Benjamin A RubinDouglas Kondziolka
Dec 21, 2018·Journal of Neurointerventional Surgery·Raoul PopRémy Beaujeux
May 2, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P DaveyB Gillies
May 12, 2019·Neurosurgery·Dale DingJason P Sheehan

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