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Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

The Journal of Biological Chemistry

May 18, 2019

Solomiia BoykoWitold K Surewicz

Abstract

Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid-liquid phase separation (LLPS). However, the mechanism of this process remains unknown. Here, we demonstrate that tau LLPS is large...read more

Mentioned in this Paper

Study
Post-Translational Protein Processing
Ions
Alzheimer's Disease
Tau Proteins
Neurodegenerative Disorders
Liquid-Liquid Extraction
Liquid Diet
Phosphorylation
19
1
78
Paper Details
References
  • References31
  • Citations3
1234
  • References31
  • Citations3
1

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Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

The Journal of Biological Chemistry

May 18, 2019

Solomiia BoykoWitold K Surewicz

PMID: 31097543

DOI: 10.1074/jbc.ac119.009198

Abstract

Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid-liquid phase separation (LLPS). However, the mechanism of this process remains unknown. Here, we demonstrate that tau LLPS is large...read more

Mentioned in this Paper

Study
Post-Translational Protein Processing
Ions
Alzheimer's Disease
Tau Proteins
Neurodegenerative Disorders
Liquid-Liquid Extraction
Liquid Diet
Phosphorylation
19
1
78

Feeds With Similar Papers

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Paper Details
References
  • References31
  • Citations3
1234
  • References31
  • Citations3
1

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