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Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases

Advances in Protein Chemistry and Structural Biology

Jan 14, 2020

Guilherme A P de OliveiraTuane C R G Vieira

Abstract

Liquid-liquid phase separation (LLPS) and phase transition (LLPT) of proteins and nucleic acids have emerged as a new paradigm in cell biology. Here we will describe the recent findings about LLPS and LLPT, including the molecular and physical determinants leading to their formation, th...read more

Mentioned in this Paper

PRNP
Caused by Mutation in the Fused in Sarcoma Gene (FUS, 137070.0007)
Mutant
Nucleic Acids
MAPT protein, human
Neurodegenerative Disorders
Major Prion Protein
Liquid Diet
Amyloid
Filling Material
12
1
9
Paper Details
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Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases

Advances in Protein Chemistry and Structural Biology

Jan 14, 2020

Guilherme A P de OliveiraTuane C R G Vieira

PMID: 31928729

DOI: 10.1016/bs.apcsb.2019.08.002

Abstract

Liquid-liquid phase separation (LLPS) and phase transition (LLPT) of proteins and nucleic acids have emerged as a new paradigm in cell biology. Here we will describe the recent findings about LLPS and LLPT, including the molecular and physical determinants leading to their formation, th...read more

Mentioned in this Paper

PRNP
Caused by Mutation in the Fused in Sarcoma Gene (FUS, 137070.0007)
Mutant
Nucleic Acids
MAPT protein, human
Neurodegenerative Disorders
Major Prion Protein
Liquid Diet
Amyloid
Filling Material
12
1
9

Similar Papers Found In These Feeds

Organelles in Neurodegeneration

Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.

Misfolding & Aggregation Diseases

Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.

Related Papers

Biochimica Et Biophysica Acta. Proteins and Proteomics

Modulation of p53 and prion protein aggregation by RNA

Biochimica Et Biophysica Acta. Proteins and ProteomicsMarch 4, 2019
Yraima CordeiroJerson L Silva
Paper Details
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