Liquid nitrogen spray cryotherapy for dysphagia palliation in patients with inoperable esophageal cancer

Gastrointestinal Endoscopy
Toufic KachaamyPankaj Vashi

Abstract

Dysphagia is a debilitating symptom in patients with inoperable esophageal cancer that contributes to poor quality of life and worsening nutritional status. The 2 most commonly used palliative modalities for dysphagia are radiation therapy and esophageal stent placement. However, radiation therapy is limited by adverse events (AEs) and total dose, and stent placement has a high rate of AEs, including reflux, migration, and chest pain. A relatively new modality of liquid nitrogen endoscopic spray cryotherapy has been described as salvage when other options have been exhausted and when patients are no longer receiving systemic therapy. We evaluated the safety and efficacy of cryotherapy as the primary modality for relieving dysphagia in inoperable esophageal cancer including patients receiving systemic cancer therapy. This is a retrospective, multicenter, consecutive case series of 49 inoperable esophageal cancer patients undergoing palliative endoscopic cryotherapy at 4 specialized cancer centers from May 2014 to May 2016. The primary outcomes were change in dysphagia scores between pre- and postcryotherapy and AEs. Dysphagia was measured using a 5-point Likert scale: 0, no dysphagia; 1, dysphagia to solids; 2, dysphagia to semi...Continue Reading

Citations

Jan 23, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hao WuTomonori Yano
Dec 31, 2019·Photochemistry and Photobiology·Tomonori Yano, Kenneth K Wang
Oct 17, 2019·ACG Case Reports Journal·Daniel MaiJason Samarasena
Dec 5, 2019·World Journal of Gastrointestinal Endoscopy·Vedha SanghiPrashanthi N Thota
Nov 30, 2018·World Journal of Gastroenterology : WJG·Pooja Lal, Prashanthi N Thota
Sep 9, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Koushik K DasVinay Chandrasekhara
Apr 5, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Osman AhmedAshley Faulx
Jul 29, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Yuri HanadaKenneth K Wang

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