Liquid-phase combinatorial synthesis of aminobenzimidazoles

Bioorganic & Medicinal Chemistry Letters
Kuo-Ting Huang, Chung-Ming Sun

Abstract

Liquid-phase synthesis of 2-arylaminobenzimidazoles using soluble polymer support strategy is first described. The key step to benzimidazole skeleton is achieved in the presence of diisopropylcarbodimide (DICDI) and isothiocyanates. A mechanism study for one-pot cyclodesulfurization is also investigated on the support. A wide range of benzimidazole derivatives is synthesized in excellent yield and purity just by simple wash and precipitation.

References

Jan 15, 2000·Bioorganic & Medicinal Chemistry Letters·A Mazurov
Apr 4, 2000·Journal of Combinatorial Chemistry·M Lebl
Apr 27, 2000·Bioorganic & Medicinal Chemistry Letters·S JinE J LaVoie
Oct 13, 2000·Journal of Combinatorial Chemistry·R E Dolle
May 29, 2001·Combinatorial Chemistry & High Throughput Screening·C M MasimirembwaT B Andersson

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