Liquid plasma: A solution to optimizing early and balanced plasma resuscitation in massive transfusion.

The Journal of Trauma and Acute Care Surgery
Genna BeattieGregory P Victorino

Abstract

Early and balanced resuscitation for traumatic hemorrhagic shock is associated with decreased mortality, making timely plasma administration imperative. However, fresh frozen plasma (FFP) thaw time can delay administration, and the shelf life of thawed FFP limits supply and may incur wastage. Liquid plasma (LP) offers an attractive alternative given immediate transfusion potential and extended shelf life. As such, we hypothesized that the use of LP in the massive transfusion protocol (MTP) would improve optimal plasma/red blood cell (RBC) ratios, initial plasma transfusion times, and clinical outcomes in the severely injured patient. Using Trauma Quality Improvement Program data from our level 1 trauma center, we evaluated MTP activations from 2016 to 2018. Type A LP use was instated April 2017. Before this, thawed FFP was solely used. Plasma/RBC ratios and initial plasma transfusion times were compared in MTP patients before and after LP implementation. Patient and injury characteristics were accounted for using linear regression analysis. Secondary outcomes of mortality, 28-day recovery, and complications were evaluated using Cox proportional hazards regression. A total of 95 patients were included (pre-LP, 39; post-LP, 56). ...Continue Reading

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Citations

Feb 20, 2021·The Journal of Trauma and Acute Care Surgery·Mohamad ChehabBellal Joseph
Jul 17, 2021·Transfusion·Henry T PengAndrew Beckett

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