Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass

The Journal of Thoracic and Cardiovascular Surgery
I M CheifetzJ N Meliones

Abstract

Neonatal and infant cardiopulmonary bypass results in multiorgan system dysfunction. Organ protective strategies have traditionally been directed at the myocardium and brain while neglecting the sometimes severe injury to the lungs. We hypothesized that liquid ventilation would improve pulmonary function and cardiac output in neonates after cardiopulmonary bypass. Twenty neonatal swine were randomized to receive cardiopulmonary bypass with or without liquid ventilation. In the liquid-ventilated group, a single dose of perflubron was administered before bypass. The control group was conventionally ventilated. Each animal was placed on nonpulsatile, hypothermic bypass. Low-flow cardiopulmonary bypass was performed for 60 minutes. The flow rate was returned to 125 ml/kg per minute, and after warming to 37 degrees C, the animals were removed from bypass. Hemodynamic and ventilatory data were obtained after bypass to assess the effects of liquid ventilation. Without liquid ventilation, cardiopulmonary bypass resulted in a significant decrease in cardiac output, oxygen delivery, and static pulmonary compliance compared with prebypass values. Input pulmonary resistance and characteristic impedance increased in these control animals. A...Continue Reading

References

Jun 1, 1978·Pediatric Research·T H ShafferM Delivoria-Papadopoulos
May 11, 1992·The Journal of Surgical Research·C H MeyersP Van Trigt
May 1, 1991·Critical Care Medicine·B P FuhrmanM DeFrancisis
Jul 1, 1990·The Journal of Pediatrics·J S GreenspanT H Shaffer
Feb 1, 1973·Anesthesiology·H W CalderwoodC I Hood
Jan 1, 1970·Thorax·C W DealI Monk
Feb 7, 1996·JAMA : the Journal of the American Medical Association·R B HirschlR H Bartlett
Jun 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·P M KirshbomJ W Gaynor
Nov 1, 1996·The Annals of Thoracic Surgery·L A SkaryakJ W Gaynor

❮ Previous
Next ❯

Citations

Aug 26, 1998·Critical Care Medicine·J N Meliones, I M Cheifetz
Dec 13, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ross M Ungerleider
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher L HubbleReese H Clark
Jun 27, 2006·The Annals of Thoracic Surgery·Lijun JiangSong Wu
Jul 9, 1999·Critical Care Medicine·D H Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Obstetrics and Gynecology
G M JacksonA W Cohen
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Alon S AharonPaul Chang
© 2022 Meta ULC. All rights reserved