Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model.

Resuscitation
Kimberly S StaffeyRichard E Kerber

Abstract

Induced external hypothermia during ventricular fibrillation (VF) improves resuscitation outcomes. Our objectives were twofold (1) to determine if very rapid hypothermia could be achieved by intrapulmonary administration of cold perfluorocarbons (PFC), thereby using the lungs as a vehicle for targeted cardiopulmonary hypothermia, and (2) to determine if this improved resuscitation success. Part 1: Nine female swine underwent static intrapulmonary instillation of cold perfluorocarbons (PFC) during electrically induced VF. Part 2: Thirty-three female swine in VF were immediately ventilated via total liquid ventilation (TLV) with pre-oxygenated cold PFC (-15 degrees C) or warm PFC (33 degrees C), while control swine received no ventilation during VF. All swine in both Parts 1 and 2 underwent VF arrest for 11 min, then defibrillation, ventilation and closed chest massage until resumption of spontaneous circulation (ROSC). The endpoint was continued spontaneous circulation for 1h without pharmacologic support. Static intrapulmonary instillation of cold PFC achieved rapid cardiopulmonary hypothermia; pulmonary artery (PA) temperature of 33.5+/-0.2 degrees C was achieved by 10 min. Nine of 9 achieved ROSC. Hypothermia was achieved fas...Continue Reading

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Citations

Sep 26, 2014·BMC Pharmacology & Toxicology·Mourad ChenouneRenaud Tissier
Mar 9, 2012·Critical Care : the Official Journal of the Critical Care Forum·Sabino ScollettaMaaret Castren
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Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·Marion LearyBenjamin S Abella
Jun 29, 2018·Chemistry : a European Journal·Yifeng PengBrian D Polizzotti
Jun 4, 2021·International Journal of Nanomedicine·Liandi HuangZhiyu Du

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