Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine

Chemico-biological Interactions
Young Woo KimSang Geon Kim

Abstract

Glycyrrhizae radix has been used as one of the oldest and most frequently employed botanicals in both western and oriental countries. Previously, we showed that liquiritigenin (LQ), an aglycone of liquiritin in G. radix, exerts cytoprotective effects against heavy metal-induced toxicity in vitro. This study investigated in vivo protective effects of LQ against acute liver injuries induced by acetaminophen (APAP) or APAP plus buthionine sulfoximine (BSO). Liver injuries were assessed by blood biochemistry and histopathology in rats administered with LQ purified from the acid hydrolyates of liquiritin singly (p.o. or i.v., 2-4 days) or in combination with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB), a synthetic derivative of Schisandrin C in Fructus shizandrae, and exposed to APAP or APAP + BSO. LQ treatments (oral) effectively decreased liver injuries induced by a single dose of APAP, as evidenced by decreases in hepatic necrosis and inflammation as well as plasma alanine aminotransferase and lactate dehydrogenase activities. LQ, when intravenously applied, enhanced hepatoprotective effect with a greater potency. APAP + BSO led to severe liver injuries, resulting in lethality. LQ pretreatm...Continue Reading

References

May 1, 1994·Journal of Ethnopharmacology·J LiuC D Klaassen
Apr 1, 1996·Chemical Research in Toxicology·J D GibsonJ A Hinson
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A BonisJ Lau
Oct 9, 2001·Nutrition and Cancer·Z Y Wang, D W Nixon
Mar 7, 2002·Toxicology Letters·Soo J OhYoung C Kim
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William M Lee
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barry H Rumack
Jan 5, 2005·Journal of Hepatology·Yasuhiro MasubuchiToshiharu Horie
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie PolsonUNKNOWN American Association for the Study of Liver Disease
Apr 30, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Miwa TakeiFujio Suzuki
Jul 14, 2005·International Journal of Molecular Medicine·Hiroshige HibasamiHidehisa Takahashi

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Citations

Feb 23, 2013·Journal of Agricultural and Food Chemistry·Charlotte SimmlerGuido F Pauli
Jan 10, 2009·Journal of Agricultural and Food Chemistry·Bolleddula JayaprakasamXiu-Min Li
Mar 8, 2013·Journal of Asian Natural Products Research·Xiao-Han DaiMing-Jun Zhang
Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Sang Mi ShinSung Hwan Ki
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Jong Rok LeeSang Chan Kim
Nov 12, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·ZhengLin ZhaoRongJie Zhao
Feb 20, 2009·Journal of Pharmaceutical Sciences·Hee E KangMyung G Lee
Dec 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hee E KangMyung G Lee
May 6, 2011·Environmental Toxicology·Saber SakrDoaa El-Sahra
Mar 13, 2014·Biomedical Chromatography : BMC·Wei ZhangJin-ao Duan
Dec 3, 2009·Phytotherapy Research : PTR·Ming ZhouYunqing Cai
Oct 15, 2014·Journal of Gastroenterology and Hepatology·Joon Ki MinJae Myung Cha
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Seong Kyu ParkSang Chan Kim
Jun 19, 2007·The Journal of Biological Chemistry·Sho AkaiTsuyoshi Yokoi
Jul 5, 2017·Clinical Pharmacology and Therapeutics·Guoxiang XieWei Jia
Oct 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingyue XuNing Zhang
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Chang-qing YangTetsumi Irie
Dec 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Young Woo KimSang Geon Kim
Dec 3, 2013·Natural Product Reports·Hemant KumarDong-Kug Choi

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