Liraglutide and cardiovascular outcomes in a real world type 2 diabetes cohort

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Marco MiraniCesare C Berra

Abstract

In the last years, due to new regulatory guidelines requiring a stringent documentation of cardiovascular (CV) safety of novel drugs for type 2 diabetes, cardiovascular outcomes safety trials (CVOTs) are requested. CVOTs increase the knowledge about the safety profile of the new drugs, but they have intrinsic limits that make difficult their transferability to clinical practice. For this reason, real world evidence is considered an important complement to experimental data. Among the glucagon-like peptide-1 receptor agonists, liraglutide in the LEADER CVOT demonstrated superiority in reducing the risk of major CV events (MACEs) vs. placebo. We conducted an observational, retrospective, longitudinal study based on 307 patients with T2DM treated with liraglutide under routine clinical practice conditions. Real world impact of liraglutide on metabolic control, CV risk factors, hypoglycemia and CV events was assessed. Improvements during 36 months were found in HbA1c (-1.0%; p < 0.0001), fasting blood glucose (-17.6 mg/dL; p < 0.0001), body weight (-3.2 kg; p < 0.0001), waist circumference (-1.45 cm; p = 0.004), systolic blood pressure (-10.41 mmHg; p < 0.0001), diastolic blood pressure (-3.69 mmHg; p < 0.0001), total cholesterol (...Continue Reading

Citations

Mar 27, 2019·Journal of Diabetes Research·Érika B RangelJoão R de Sá
Jul 11, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C BerraF Folli
May 22, 2021·Journal of the American College of Cardiology·Nadia AkawiCharalambos Antoniades

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