Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression

Drug Design, Development and Therapy
Yimin ShaoXiaohui Guo

Abstract

Liraglutide, a glucagon-like peptide-1 analog, has been proved to reduce body weight and visceral adipose tissue (VAT) in human studies. In this study, we aimed at examining lipogenetic signal changes in VAT after weight-loss with liraglutide in db/db mice. The mice were divided into two groups: liraglutide-treated group (n=14, 8-week-old, fasting glucose. >10 mmol/L, liraglutide 300 μg/kg twice a day for 4 weeks) and control group (n=14, saline). We found body weight gain and food intake were reduced after liraglutide treatment (P<0.05). Compared to the control group, the VAT weights were significantly lower in the treated group (2.32±0.37 g versus 3.20±0.30 g, P<0.01) than that in control group. In VAT, compared with control group, the lipogenetic transcription factors PPARγ and C/EBPα expressions were both reduced with pAMPK and pACC increased 3.5-fold and 2.31-fold respectively, while pAkt and pP38MAPK were reduced 0.38-fold and 0.62-fold respectively (P<0.01). In conclusion, VAT was reduced after weight loss with AMPK activation and Akt suppression with liraglutide treatment, which was associated with reduction of lipogenetic process in VAT.

Citations

Jun 4, 2016·Nature Reviews. Drug Discovery·Christine M KusminskiPhilipp E Scherer
Mar 30, 2017·Pharmacology & Therapeutics·Miguel López, Manuel Tena-Sempere
Feb 25, 2017·European Journal of Endocrinology·Miguel López
Jul 13, 2018·European Journal of Clinical Investigation·Miguel López
May 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sha LeiWei Jia
Aug 21, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Daniela Rosendo-Silva, Paulo Matafome
Mar 30, 2018·International Journal of Endocrinology·Sofia DiasLaura Ribeiro
May 4, 2018·Journal of Biomedical Science·Katrina Weston-GreenJessica Nealon
Jan 16, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jelena JakabAleksandar Včev

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

PRISM
Primer Express

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