LIS2, gene and pseudogene, homologous to LIS1 (lissencephaly 1), located on the short and long arms of chromosome 2

Genomics
O ReinerA Cahana

Abstract

We report here the isolation of a novel cDNA, designated LIS2, that maps to chromosome 2p11.2 by in situ hybridization and demonstrates extremely high sequence similarity to the recently identified LIS1 gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes for LIS2 revealed a pattern of expression resembling that of LIS1, although LIS2 is less abundant. Surprisingly, LIS2 detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped by in situ hybridization to two loci on chromosome 2,2p11.2 and 2q13-q14. This hybridization was due to the existence of LIS2 pseudogene LIS2P on the long arm of chromosome 2.

Citations

Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Victor SoukoulisDavid M Bader
Jul 1, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Ilya M Nasrallah, Jeffrey A Golden
May 14, 1999·American Journal of Medical Genetics·A PeifferJ C Carey
Aug 31, 2000·Molecular Neurobiology·O Reiner
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clifford Hudis
Feb 1, 2011·Proteomics·Herman H H B M van HaagenMartijn J Schuemie

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