Lisinopril. A review of its pharmacology and use in the management of the complications of diabetes mellitus

Drugs
K L GoaM I Wilde

Abstract

Lisinopril, like other ACE inhibitors, lowers blood pressure and preserves renal function in hypertensive patients with non-insulin-dependent or insulin-dependent diabetes mellitus (NIDDM or IDDM) and early or overt nephropathy, without adversely affecting glycaemic control or lipid profiles. On available evidence, renoprotective effects appear to be greater with lisinopril than with comparator calcium channel blockers, diuretics and beta-blockers, despite similar antihypertensive efficacy. As shown by the EUCLID (EUrodiab Controlled trial of Lisinopril in Insulin-Dependent Diabetes) trial, lisinopril is also renoprotective in normotensive patients with IDDM and microalbuminuria. The effect in normotensive patients with normoalbuminuria was smaller than in those with microalbuminuria, and no conclusions can yet be made about its use in patients with normoalbuminuria. In complications other than nephropathy, lisinopril has shown some benefit. Progression to retinopathy was slowed during 2 years' lisinopril therapy in the EUCLID study. Although not yet fully published, these results provide the most convincing evidence to date for an effect of an ACE inhibitor in retinopathy. The drug may also improve neurological function, but t...Continue Reading

Citations

Nov 8, 2013·Chemical Communications : Chem Comm·Tsuyoshi MinamiPavel Anzenbacher
Nov 13, 2009·Diabetes Technology & Therapeutics·Mohammad E KhamsehHamid R Baradaran
Jun 1, 2013·Expert Review of Ophthalmology·Mohamed Al-ShabraweyAmany Tawfik

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