Lisinopril dose-response relationship in essential hypertension

British Journal of Clinical Pharmacology
H J GomezE P MacCarthy


1. This was a multicentre, double-blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95-115 mm Hg) essential hypertension. 2. After a 4-week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5.20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2, 0, 2, 4, and 6. 3. There was a linear dose-response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups. 4. Lisinopril, at doses up to 80 mg day-1, was well tolerated.


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Related Concepts

Angiotensin-Converting Enzyme Inhibitors
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Double-Blind Method
Pulse Rate
Hypertensive Disease
Controlled Clinical Trials, Randomized
Lisinopril Sulfate (1:2)

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