Lisinopril dose-response relationship in essential hypertension

British Journal of Clinical Pharmacology
H J GomezE P MacCarthy

Abstract

1. This was a multicentre, double-blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95-115 mm Hg) essential hypertension. 2. After a 4-week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5.20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2, 0, 2, 4, and 6. 3. There was a linear dose-response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups. 4. Lisinopril, at doses up to 80 mg day-1, was well tolerated.

References

Jan 1, 1987·Journal of Cardiovascular Pharmacology·H J GomezF Moncloa
Jan 1, 1987·Journal of Cardiovascular Pharmacology·C MörlinK A Meurer
Jan 1, 1987·Journal of Cardiovascular Pharmacology·P K ZachariahF G McMahon
Jan 1, 1987·Journal of Cardiovascular Pharmacology·F FyhrquistI L Junggren
Jan 1, 1987·Journal of Cardiovascular Pharmacology·J F DonohoeW D Cooper
Jan 1, 1987·Journal of Cardiovascular Pharmacology·J P ChalmersP Schuster
Jan 1, 1987·Journal of Cardiovascular Pharmacology·J E Rush, D D Merrill
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A Leal-CerroR Astorga
May 1, 1985·British Journal of Clinical Pharmacology·R BergstrandJ A Bolognese
Jan 1, 1988·European Journal of Clinical Pharmacology·R Schmidt
Sep 1, 1982·British Journal of Clinical Pharmacology·E H UlmJ L Schelling

Citations

Nov 8, 2006·European Journal of Clinical Pharmacology·G A ChristieW S Waring
Oct 24, 2012·Computational and Mathematical Methods in Medicine·Yinzi RenGangmin Ning
Sep 8, 2010·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sal BottiglieriVal Adams
Feb 14, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Peter Jacobsen
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Balraj S HeranJames M Wright
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Peter JacobsenHans-Henrik Parving

Related Concepts

Angiotensin-Converting Enzyme Inhibitors
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Double-Blind Method
Renitec
Pulse Rate
Hypertensive Disease
Controlled Clinical Trials, Randomized
Lisinopril Sulfate (1:2)

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.